Interleukin-33, oxidative stress in prediabetic polycystic ovary syndrome patients with insulin resistance
المؤلفون المشاركون
al-Rabii, Zaynab Munib Malik
al-Tai, Wafa F.
Hasan, Abir Jabbar
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 56، العدد 1 (31 مارس/آذار 2014)، ص ص. 113-117، 5ص.
الناشر
تاريخ النشر
2014-03-31
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Polycystic ovary syndrome (PCOS) is one of the common female endocrine disorders of uncertain etiology, which causes menstrual disorders as well as infertility.
Interleukin-33(IL-33) is considered as a strong risk marker of inflammation and may have possible role in pathogenesis of PCOS.
Objectives : The present study is designed to investigate the possible role of IL-33 in pathogenesis of PCOS and its relation with glycated hemoglobin (HbA 1C), insulin resistance(IR) and oxidative stress in prediabetic PCOS patients.
Subjects and Methods : The study involved 30 healthy women as control group and sixty six infertile Iraqi women with PCOS which were divided into two groups according to glycated heamoglobin(HbAlc) value and homeostasis model assessment for insulin resistance (HOMA-IR).
The first group (Gl) consist of 30 women with HbAlc < 6.5 % and HOMA -IR<3.8 as PCOS without diabetes and without insulin resistance.
The second group (G2) consist of 36 patients with HbAlc > 6.5 % and IIOMA-IR> 3.8 as PCOS with pre diabetes type 2 and insulin resistance.
Ten milliliters of blood were collected from all subjects by vein puncture during 2nd - 4th day of the menstrual cycle.
Two ml of blood were collected in EDTA tube for HbAlc analysis.
The serum which obtained from the remained blood were used for determination of (insulin, fasting blood glucose(FBG), Malondialdehyde(MDA), Total antioxidant capacity(TAC), uric acid, glutathione(GSH), albumin, and IL-33).
Results : Results revealed a significant elevation in HbAlc, insulin, HOMA-IR, MDA, TAC, uric acid and IL-33 in the patients group when compared with healthy women.
On the other hand, a significant decreased in GSH and albumin were found in patients group when compared with control group.
Also there are significant differences in the results between patients in group 1 and group 2.
A significant positive correlation between IL-33 and HbAlc levels was noticed in Gl and G2 .A significant positive correlation between IL-33 and HOMA-IR was noticed in group 1 while a negative significant correlation was found in group 2.
No correlation founded between IL-33 levels and TAC concentration in group 1, but a positive correlation noticed with group 2.
A significant negative correlation was observed between IL-33 and MDA / TAS ratio in Gl, while a significant positive correlation in G2 was found.
Conclusion : high levels of IL-33 in patient groups may be considered as a novel cytokine involved in the pathogenesis of PCOS.
Also the elevation in oxidative stress in PCOS patients could be a reason for disturbed follicular development and ultimately infertility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Tai, Wafa F.& al-Rabii, Zaynab Munib Malik& Hasan, Abir Jabbar. 2014. Interleukin-33, oxidative stress in prediabetic polycystic ovary syndrome patients with insulin resistance. Journal of the Faculty of Medicine Baghdad،Vol. 56, no. 1, pp.113-117.
https://search.emarefa.net/detail/BIM-385052
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Tai, Wafa F.…[et al.]. Interleukin-33, oxidative stress in prediabetic polycystic ovary syndrome patients with insulin resistance. Journal of the Faculty of Medicine Baghdad Vol. 56, no. 1 (2014), pp.113-117.
https://search.emarefa.net/detail/BIM-385052
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Tai, Wafa F.& al-Rabii, Zaynab Munib Malik& Hasan, Abir Jabbar. Interleukin-33, oxidative stress in prediabetic polycystic ovary syndrome patients with insulin resistance. Journal of the Faculty of Medicine Baghdad. 2014. Vol. 56, no. 1, pp.113-117.
https://search.emarefa.net/detail/BIM-385052
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 116-117
رقم السجل
BIM-385052
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر