Pharmacological effects of diclofenac sodium on some hematological parameters of male rabbits

الملخص EN

Diclofenac sodium isa non steroidal anti inflammatory drug (NSAIDs).

The present study was conducted to assess the effects of Diclofenac sodium on some hematological parameters,on male rabbits.

The study was carried out in the animal house of College of Medicine-Babylon University at the period from 1 Dec.

2009 -1Mar.

2010.

Twenty local male rabbits were divided in to two groups, (control and treatment ).The drug was given intramuscularly once a day.

Along the study period Diclofenac sodium is given for 45 days and, blood samples were obtained every 15 days for hematological study , while at day 60 blood samples are used for hematological and immunological study.

As a results of this study,Diclofenac cause significant decrease (p < 0.05) in hemoglobin conc.

and hematocrit percentage and significant increase (p < 0.05) in reticulocyt percentage as compared with control group.

As for WBCs related parameters there is non significant difference (p > 0.05) in total WBCs count of all the three treated group as compared with control group.

On the other hand differential WBCs count show significant decrease (p < 0.05) in neutrophils count and significant increase (p < 0.05) in lymphocytes count of treated group as compared with control group.

Diclofenac treated animals show erythroid hyperplasia.

In conclusion Diclofenac used in this study caused anemia and neutropenia and these effects were due to immune and non immune mechanisms.