Immunohistochemical expression of p53 and PCNA proteins in oral lichen planus and oral dysplasia
المؤلفون المشاركون
al-Azzawi, Lihadh M.
al-Ani, Layla S.
المصدر
Journal of Baghdad College of Dentistry
العدد
المجلد 26، العدد 1 (31 مارس/آذار 2014)، ص ص. 98-102، 5ص.
الناشر
تاريخ النشر
2014-03-31
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Classified among the potentially malignant lesions of oral mucosa.
The aim of this study is to investigate and compare the expression of p53 and PCNA proteins in oral lichen planus and epithelial dysplasia cases.
Materials and methods : Formalin-fixed and paraffin- embedded blocks of 21 lichen planus and 21 oral dysplasia cases were referred to immunohistochemical (IHC) analysis for anti p53 and anti PCNA monoclonal antibodies.
Results : The results showed that positive nuclear staining for p53 was found in 11 / 21 (52.4 %) cases of lichen planus and 17 / 21 (80.9 %) cases of dysplasia.
Positivity for PCNA was observed in 18 / 21(85.7 %) of oral lichen planus cases, and 19 / 21(90.5 %) of epithelial dysplasia cases.
There was a statistically significant difference between the expression of p53 and PCNA proteins in oral lichen plauns cases and non- significant differences of either protein expression in oral dysplasia cases.
No statistically significant difference of p53 and PCNA proteins expression between oral lichen planus and epithelial dysplasia cases was found.
Moreover, there was no significant difference in P53 and PCNA expression with respect to the grade of epithelial dysplasia.
Conclusion : The proportion of cases with positive p53 expression increased from lichen planus to dysplasia.
These results may indicate an involvement of p53 in neoplastic transformation as well as in proliferative events PCNA, although the absence of p53 staining could be used to predict the outcome of potentially malignant oral mucosal lesions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Azzawi, Lihadh M.& al-Ani, Layla S.. 2014. Immunohistochemical expression of p53 and PCNA proteins in oral lichen planus and oral dysplasia. Journal of Baghdad College of Dentistry،Vol. 26, no. 1, pp.98-102.
https://search.emarefa.net/detail/BIM-387233
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Azzawi, Lihadh M.& al-Ani, Layla S.. Immunohistochemical expression of p53 and PCNA proteins in oral lichen planus and oral dysplasia. Journal of Baghdad College of Dentistry Vol. 26, no. 1 (Mar. 2014), pp.98-102.
https://search.emarefa.net/detail/BIM-387233
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Azzawi, Lihadh M.& al-Ani, Layla S.. Immunohistochemical expression of p53 and PCNA proteins in oral lichen planus and oral dysplasia. Journal of Baghdad College of Dentistry. 2014. Vol. 26, no. 1, pp.98-102.
https://search.emarefa.net/detail/BIM-387233
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendix : p. 102
رقم السجل
BIM-387233
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر