Immunohistochemical expression of ICAM-1 and cortactin as cell adhesive molecule and invasive markers in hodgkin’s and non-hodgkin’s lymphoma of the head and neck region : a comparative study
المؤلفون المشاركون
Yunus, Wasan H.
Qasim, Zaydun Mahmud
المصدر
Journal of Baghdad College of Dentistry
العدد
المجلد 26، العدد 2 (30 يونيو/حزيران 2014)، ص ص. 103-110، 8ص.
الناشر
تاريخ النشر
2014-06-30
دولة النشر
العراق
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Nodes and cause the characteristic clinical features of lymphadenopathy.
Intercellular adhesion molecule-1 (ICAM-1) (CD54) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily of adhesion molecules.
Cortactin was first identified as one of the major substrates for src kinase.
because it localized to Cortical actin structures, The aims of this study was to evaluate and compare the immunohistochemical of ICAM-1 expression as cell adhesion molecule marker and Cortactin expression as invasive marker.
Material and Methods : This study was performed on (68) formalin-fixed, paraffin-embedded blocks, histopathologically diagnosed as lymphoma (head and neck lesions).Immunohistochemical staining of ICAM-1and Cortactin was performed on each case of the study sample.
Results : The expression of ICAM-1 was membranous and cytoplasmic, the study cases showed a 98.5 % positive reaction to ICAM-1, score 2 was the most common and found in 69.1 % of all cases.
The expression of Cortactin was cytoplasmic, 98.5 % of cases expressed positive reactions to Cortactin, score 1 was the most common and found in 42.7 % of all cases.
Conclusion : Although the two markers showed a higher expression rate in all lymphomas (both HL and NHL) in this study, they can't be used to differentiate between them, nor can be used to differentiate between the subtypes of both HL and NHL.
The high ICAM-1positive expression clarified that in addition to its role in cell-cell and cell-stromal interactions, it participates in proliferation, differentiation and invasion of malignant lymphoma cells.
The present study is the first one that used Cortactin as an invasive marker for lymphoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qasim, Zaydun Mahmud& Yunus, Wasan H.. 2014. Immunohistochemical expression of ICAM-1 and cortactin as cell adhesive molecule and invasive markers in hodgkin’s and non-hodgkin’s lymphoma of the head and neck region : a comparative study. Journal of Baghdad College of Dentistry،Vol. 26, no. 2, pp.103-110.
https://search.emarefa.net/detail/BIM-387342
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qasim, Zaydun Mahmud& Yunus, Wasan H.. Immunohistochemical expression of ICAM-1 and cortactin as cell adhesive molecule and invasive markers in hodgkin’s and non-hodgkin’s lymphoma of the head and neck region : a comparative study. Journal of Baghdad College of Dentistry Vol. 26, no. 2 (Jun. 2014), pp.103-110.
https://search.emarefa.net/detail/BIM-387342
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qasim, Zaydun Mahmud& Yunus, Wasan H.. Immunohistochemical expression of ICAM-1 and cortactin as cell adhesive molecule and invasive markers in hodgkin’s and non-hodgkin’s lymphoma of the head and neck region : a comparative study. Journal of Baghdad College of Dentistry. 2014. Vol. 26, no. 2, pp.103-110.
https://search.emarefa.net/detail/BIM-387342
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 109-110
رقم السجل
BIM-387342
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر