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The association of polymorphic sites in some genes with type 1 diabetes mellitus in a sample of Egyptian children
المؤلفون المشاركون
Imbabi, Amirah Muhammad
Dawuds, Ali Salim
al-Kafuri, Ahmad A.
Harun, Midhat
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 15، العدد 3 (31 يوليو/تموز 2014)، ص ص. 265-272، 8ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2014-07-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
-Background: The major histocompatibility complex (MHC) genes have been implicated as the major genetic component in the predisposition to type 1 diabetes mellitus (T1DM).
Other loci outside the MHC had also been reported to contribute in the susceptibility of T1DM.
The aim of this study was to examine the role of some variants of polymorphic sites in some genes associated with T1DM in a sample of Egyptian children.
Patients and methods: 60 patients with T1DM from the diabetes clinic at Alexandria University Children’s Hospital, and 60 healthy individuals were enrolled in this study.
Genomic DNA was extracted using isopropanol precipitation method.
Interleukin 18 (IL-18), interleukin 10 (IL-10), vitamin D receptor (VDR), protein tyrosine phosphatase non-receptor type 22 (PTPN22) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) were genotyped.
Results: The findings obtained from logistic regression analysis suggest that the IL-18 single nucleotide polymorphisms SNP-137 G>C (rs#187238), the VDR Fok1 SNP T>A (rs#2228570) and the SNP-1123 C>G (rs#2488457) in PTPN22 gene showed a significant difference between patients and controls (P = 0.026, 0.030, and 0.003, respectively).
The genotype distributions of PTPN22 SNP-1858, CTLA-4 SNP 49, IL-10 SNP-819, IL-18 SNP-607, and VDR BsmI SNP G>A did not show any significant difference.
Conclusion: The IL-18 SNP-137 G>C (rs#187238), VDR SNP-Fok1 T>A (rs#2228570), and the SNP-1123 C>G (rs#2488457) in PTPN22 gene may have an effect on the occurrence Corresponding author.
Address: Alexandria University Children’s Hospital, 77 Al Fath Street, Fleming, Alexandria, Egypt.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Kafuri, Ahmad A.& Harun, Midhat& Imbabi, Amirah Muhammad& Dawuds, Ali Salim. 2014. The association of polymorphic sites in some genes with type 1 diabetes mellitus in a sample of Egyptian children. The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 3, pp.265-272.
https://search.emarefa.net/detail/BIM-388683
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Kafuri, Ahmad A.…[et al.]. The association of polymorphic sites in some genes with type 1 diabetes mellitus in a sample of Egyptian children. The Egyptian Journal of Medical Human Genetics Vol. 15, no. 3 (Jul. 2014), pp.265-272.
https://search.emarefa.net/detail/BIM-388683
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Kafuri, Ahmad A.& Harun, Midhat& Imbabi, Amirah Muhammad& Dawuds, Ali Salim. The association of polymorphic sites in some genes with type 1 diabetes mellitus in a sample of Egyptian children. The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 3, pp.265-272.
https://search.emarefa.net/detail/BIM-388683
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 271-272
رقم السجل
BIM-388683
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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