Inhibitory effects of synthetic glucocorticoids drugs on hypothalamus-pituitary-adrenal gonads axes and differential white blood cells in asthmatic patients

الملخص EN

The present study focused on the different effects of synthetic glucocorticoids therapies on different hormones and white blood cells of asthmatic patients of both sexes.

The present study included 80 asthmatic patients (40 males and 40 females) and sub divided into two categories : first group involved asthmatic patients treated with glucocorticoid therapies (20 males and 20 females) and second group included asthmatic patients treated without glucocorticoids therapies (20 males and 20 females).

A thirty healthy subjects were involved in this study to perform comparison (control group) of both sexes (15 males and 15 females).

All ages of the subjects ranged between 30–60 years old.

Result of cortisol, testosterone, estradiol hormones showed significant decrease (P < 0.01) in first group (treated with glucocorticoids) and showed insignificant changes in the second group when compared with healthy control group.

Concerning values of total white blood cells pointed out significant increase (P < 0.05) in both patients group when compared with control group.

Differential white blood cells of first asthmatic patients group, explained significant increase in the levels of monocytes, neutrophils and insignificant increase in the levels of eosinophils and of lymphocytes when compared with control group.

Moreover, results of differential white blood cells of second patients group (without glucocorticoids therapies) recorded a significant increase (P < 0.05) in the levels of monocytes, eosinophils, neutrophils, and insignificant changes of lymphocytes in a comparison with control group.

In conclusion, changes mentioned above may be attributed mainly to inhibitory effects of synthetic glucocorticoids on axes of hypothalamu –pituitary– adrenal axes, and of reproduction, growth, maturation, and migration of white blood cells.