Contribution of IL-10 (SNP-819 C T and SNP-1082 G A)‎ polymorphisms variants to the risk of type 1 diabetes in Egyptian population

الملخص EN

This study investigated whether interleukin- 10 (IL-10) gene promoter region polymorphisms are associated with susceptibility or clinical presentation of type 1 diabetes.

The frequency of -1082G / A and -819C / T, polymorphisms was analyzed in 60 Egyptian patients with type 1 diabetes and in 60 healthy control subjects in a case-controlled study.

However, the -819C / T not showed significance between patient and control (P = 0.208) and 1082G / A were associated with T1DM disease (P < 0.0001).

These results suggest that the IL-10 gene promoter polymorphisms are associated with type 1 diabetes in Egyptian population.