Is insulin resistance an independent risk factor for atherosclerosis in type 2 diabetes ?
المؤلفون المشاركون
al-Badawi, Muhammad
Husayn, Nabilah Ali
al-Badri, Mahmud
al-Fawwal, Faridah M.
Uthman, Fayruz
Umar, Hisham Muhammad
المصدر
Egyptian Journal of Applied Endocrinology
العدد
المجلد 18، العدد 1 (31 يناير/كانون الثاني 2000)، ص ص. 29-42، 14ص.
الناشر
الجمعية المصرية للغدد الصماء التطبيقية
تاريخ النشر
2000-01-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
In the present study, we aimed to assess the effects of candidate atherosclerosis risk factors including plasma insulin and insulin resistance on carotid artery intimal -medial thickness (IMT) as an early marker for atherosclerosis in 30 type 2 diabetes patients as well as in 30 age and sex matched nondiabetic subjects.
In both groups, IMT was measured by B-mode ultrasonography while candidate atherosclerosis risk factors were also measured.
Insulin sensitivity and reciprocally insulin resistance was assessed by calculating plasma glucose disappearance rate after intravenous insulin injection (Kitt).
Our results showed that IMT was significantly higher in diabetics compared to nondiabetics (1.36 ± 0.28 mm versus 1.14 ±0.21 mm, P<0.005).
Of all candidate risk factors body mass index systolic blood pressure, fasting insulin, as well as the frequency of hypertension and dyslipidemia were significantly higher in diabetic patients.
Importantly, Kitt was significantly lower in diabetics compared to non diabetics (3.84 ± 0.99 % / minute versus 6.95 ± 0.81% / minute, P<0.001), indicating lowered insulin sensitivity and reciprocally increased insulin resistance.
Simple regression analysis revealed significant negative correlation betM’een IMT and Kitt in either diabetics (r = - 0.66, P < 0.01) or nondiabetics (r = -0.63, P < 0.01).
Stepwise multiple regression analysis showed independent association between IMT and both body mass index and waist-to-hip ratio in diabetics as well as in nondiabetics, while IMT was independently associated with Kitt only in diabetics.
Plasma insulin was not independently associated with IMT in both groups.
Our results indicate that type 2 diabetes is characterized by greater thickness of the carotid artery, and that atherosclerosis is independently.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Badri, Mahmud& al-Badawi, Muhammad& Husayn, Nabilah Ali& al-Fawwal, Faridah M.& Umar, Hisham Muhammad& Uthman, Fayruz. 2000. Is insulin resistance an independent risk factor for atherosclerosis in type 2 diabetes ?. Egyptian Journal of Applied Endocrinology،Vol. 18, no. 1, pp.29-42.
https://search.emarefa.net/detail/BIM-392882
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Badri, Mahmud…[et al.]. Is insulin resistance an independent risk factor for atherosclerosis in type 2 diabetes ?. Egyptian Journal of Applied Endocrinology Vol. 18, no. 1 (Jan. 2000), pp.29-42.
https://search.emarefa.net/detail/BIM-392882
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Badri, Mahmud& al-Badawi, Muhammad& Husayn, Nabilah Ali& al-Fawwal, Faridah M.& Umar, Hisham Muhammad& Uthman, Fayruz. Is insulin resistance an independent risk factor for atherosclerosis in type 2 diabetes ?. Egyptian Journal of Applied Endocrinology. 2000. Vol. 18, no. 1, pp.29-42.
https://search.emarefa.net/detail/BIM-392882
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendices : p. 39-42
رقم السجل
BIM-392882
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر