Immunoregulatory and cytokine imbalances in children with insulin-dependent diabetes mellitus (IDDM)
المؤلفون المشاركون
Abd al-Rahman, Hanan Amin
Abd Allah, Sumayyah Hasan
Sharif, Layla M.
Abu al-Majd, Yusra al-Sayyid
Hisham, Mirfat Abd Allah
المصدر
Egyptian Journal of Applied Endocrinology
العدد
المجلد 18، العدد 1 (31 يناير/كانون الثاني 2000)، ص ص. 123-130، 8ص.
الناشر
الجمعية المصرية للغدد الصماء التطبيقية
تاريخ النشر
2000-01-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The present study was planned to determine the role of cytokines in the development of insulin-dependent diabetes mellitus (IDDM).
Serum levels of cytokines derived from T helper 1 (interleukin-2 and interferon-gamma), T helper 2 (interleukin-10), lymphocytes and macrophages (tumour necrosis factor-alpha) were measured in 30 IDDM children and 15 age and sex matched healthy controls.
The diabetic children were classified into two groups according to disease duration (recently diagnosed IDDM <6 months and long standing IDDM patients >J8 months).
Our study revealed that recently diagnosed IDDM patients had significantly higher levels of IL-2, interferon-gamma (IFN-gamma) and TNF-a than patients with long standing IDDM.
Compared with control subjects, IDDM patients had higher levels of all cytokines (<0.001).
Also it was found that there was no correlation between different cytokines and age as well as the level °f glycated hemoglobin (HbAlc) among IDDM patients, but as regard duration °.f the disease, there was significant negative correlation with the levels of IFN-gamma, IL-2 and TNF-a but no significant difference with IL-10.
These results support the notion that T helper 1 lymphocytes may play a role in the development of IDDM.
This is associated with the release of macrophage -derived cytokines, which is also a feature of the prediabetic period.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharif, Layla M.& Hisham, Mirfat Abd Allah& Abd al-Rahman, Hanan Amin& Abu al-Majd, Yusra al-Sayyid& Abd Allah, Sumayyah Hasan. 2000. Immunoregulatory and cytokine imbalances in children with insulin-dependent diabetes mellitus (IDDM). Egyptian Journal of Applied Endocrinology،Vol. 18, no. 1, pp.123-130.
https://search.emarefa.net/detail/BIM-392941
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharif, Layla M.…[et al.]. Immunoregulatory and cytokine imbalances in children with insulin-dependent diabetes mellitus (IDDM). Egyptian Journal of Applied Endocrinology Vol. 18, no. 1 (Jan. 2000), pp.123-130.
https://search.emarefa.net/detail/BIM-392941
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharif, Layla M.& Hisham, Mirfat Abd Allah& Abd al-Rahman, Hanan Amin& Abu al-Majd, Yusra al-Sayyid& Abd Allah, Sumayyah Hasan. Immunoregulatory and cytokine imbalances in children with insulin-dependent diabetes mellitus (IDDM). Egyptian Journal of Applied Endocrinology. 2000. Vol. 18, no. 1, pp.123-130.
https://search.emarefa.net/detail/BIM-392941
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 127-129
رقم السجل
BIM-392941
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر