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Effect of smoking on cell adhesion molecules in normoalbuminuric type 2 diabetes mellitus
المؤلفون المشاركون
المصدر
Egyptian Journal of Applied Endocrinology
العدد
المجلد 19، العدد 1-2 (31 يوليو/تموز 2001)، ص ص. 33-44، 12ص.
الناشر
الجمعية المصرية للغدد الصماء التطبيقية
تاريخ النشر
2001-07-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
It was recently suggested that smoking, in addition to its well-known cardiovascular consequences, could accelerate the progression of renal diseases.
Also, increasing evidence suggests that chronic smoking adversely influence the prognosis of diabetic nephropathy.
A higher level of cAM, particularly cICAM-1 has been found in nondiabetic smokers compared with non-smokers.
However, no data available regarding the effect of chronic cigarette smoking on the plasma clCAM-1 levels in type 2 diabetes mellitus.
Thus, the aim of this study was to evaluate the effect of chronic cigarette smoking on plasma cICAM-1 levels in a gi'oup of normoalbuminuric type 2 diabetic patients.
MATERIAL AND METHODS The study group comprised 75 subjects; a diabetic group consisted of 50patients (30 males and 20 females, their mean age was 48.36±8.7 years) and a non-diabetic control group consisted of 25 subjects (15 males and 10 females, their mean age was 47.5±9.1 years).
Both groups were subdivided into nonsmoker and smoker groups.
Both groups were matched for age, sex and smoking percentage.
All members of the study were subjected to: Thorough medical history and clinical examination, assay of plasma total cholesterol, triglycerides, HDL, glycohemoglobin, insulin and cICAM-1 and urinary albumin excretion rate (AER).
RESULS: The BMI (p<0.05) and the FPG, insulin, HbAlc, and triglycerides were significantly higher in the diabetic subjects compared to the control group (p<0.001).
The cICAM-1 concentrations were highly significantly elevated in the diabetic group compared to the control group (303±99 Vs 229±5 5 ng/ml, p<0.001).
The cl CAM-1 concentrations were significantly elevated in the smoker diabetic subjects compared to the nonsmoker diabetic subjects (323±71 Vs 285±43 ng/ml, p<0.01).
The cl CAM-1 concentrations were significantly elevated in the smoker diabetic subjects and nonsmoker diabetic subjects compared to the control group (323±71 and 285±43 Vs 229±55 ng/ml, p<0.001).
There was a significant correlation between cICAM-1 and fasting plasma glucose, HbAlc and fasting insulin.
CONCLUSION: There is an increased level of cICAM-1 in normoalbuminuric types 2 diabetic patients.
Furthermore, cigarette smoking has an additional deleterious effect on the level of cICAM-1, which supports the importance of promoting smoking cessation and discouraging the initiation of smoking in people with type 2 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sarhan I. I.& Zakariyya N. A.. 2001. Effect of smoking on cell adhesion molecules in normoalbuminuric type 2 diabetes mellitus. Egyptian Journal of Applied Endocrinology،Vol. 19, no. 1-2, pp.33-44.
https://search.emarefa.net/detail/BIM-393189
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sarhan I. I.& Zakariyya N. A.. Effect of smoking on cell adhesion molecules in normoalbuminuric type 2 diabetes mellitus. Egyptian Journal of Applied Endocrinology Vol. 19, no. 1-2 (Jan. / Jul. 2001), pp.33-44.
https://search.emarefa.net/detail/BIM-393189
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sarhan I. I.& Zakariyya N. A.. Effect of smoking on cell adhesion molecules in normoalbuminuric type 2 diabetes mellitus. Egyptian Journal of Applied Endocrinology. 2001. Vol. 19, no. 1-2, pp.33-44.
https://search.emarefa.net/detail/BIM-393189
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendices : p. 43-44
رقم السجل
BIM-393189
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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