Effect of low dose folic acid versus estrogen replacement on plasma homocysteine in postmenopausal women

الملخص EN

Objective : to compare the effect of estrogen versus low dose folic acid on total homocysteine- plasma level (tHCY).

Study design : One hundred hysterectomized postmenopausal women were randomized into 2 groups.

One group receiving estrogen and progestrogen the other receiving folic acid 500 mg / day.

Results : Plasma tHCY was significantly lowered in both group after 3 months of supplementation (8.8 ± 2.25 μmol / l versus 5.2 ± 2.25 μmol / l) in group receiving estrogen versus (7.6 ± 1.35 μmol / l and 5.3 ± 2.15 μmol / 1) in group receiving folic acid (P < 0.01).

Conclusion : Low dose folic acid has the same effect in lowering plasma tHCY in postmenopausal women.