Synthesis and biological activity of new pyrazoline and pyrazole derivatives

الملخص EN

Condensation of p-sulfamylphenylhydrazine with chalcones, leads either to hydrazones 2 or to pyrazolines 3.

Oxidation of 3 afforded py-razoie derivatives 4.

Benzenesulfonylureas 5 and thioureas 6 were also prepared.

Cyclization of the-thioureido group of compounds 6 by treating with ethyl bromoacetate, ethyl P-bromopropionate and a-bromoacetophenone afforded the corresponding thiazolidinone, thiazinone and thiazoline derivatives 7, 8, 9 respectively.

The biological activity of the prepared compounds were also studied and they were found inactive.