A new synthetic approach to tv-protected amino aldehydes

الملخص EN

N-Protected (Boc- & Z-) L-a-amino acids have been converted to activated mixed anhydrides by reaction either with N,N-dimethylchloroiminium chloride to form (in situ) the imidate or with diethyl phosphorochloridate in the presence of pyridine.

Subsequent reduction of these anhydrides using either DIBAL or lithium tri-/-butoxyaluminum hydride gives the corresponding aldehydes.

Keywords: Organic Chemistry/Amino Acids, Peptides, and Proteins.