Systemic absorption of chloramphenicol eye drops

الملخص EN

Chloramphenicol blood levels were measured in 11 patients re-ceiving ehlorrophenicol eye drops for a period from 9-19 days, peripheral blood counts were also examined before and after therapy.

Chloram-phenicol was detected in the plasma of all the 1 ل patients.

Levels above the lower limit of laboratory measurements were found in 7 of the 11 patients (Range 2.5-5 mg/ml).

There was no change in the peripheral blood count following the use of the drug.

The bone marrow aplasia reported with topi-cal chloramphenicol drops is most likely to be due to idiosyncratic reaction rather than direct dose related reaction.

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