Association of Angiotensin-converting enzyme gene dimorphisms with severity of lupus diseases
المؤلفون المشاركون
Rabbani, Malik Hasan
Mahmud, M. Saeed
Mekan, Sabeen Fatima
Frossard, Philippe M.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 19، العدد 5 (31 أكتوبر/تشرين الأول 2008)، ص ص. 761-766، 6ص.
الناشر
تاريخ النشر
2008-10-31
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Angiotensin-converting enzyme (ACE) plays an important role in the development of systemic lupus erythematosus (SLE) because its end-product, angiotensin II, plays an integral role in the regulatory system responsible for endothelial control and vascular tone, systems that are commonly affected in patients with SLE.
Additionally, ACE inhibitors have been shown to retard the progression of SLE and lupus nephritis.
Our goal was to investigate whether ACE gene polymorphisms are associated with increasing severity of SLE.
We genotyped 39 SLE patients of varying disease severity from a homogenous Asian population and 79 control subjects for ACE I / D and 2350 G > A dimorphisms.
All patients met the American College of Rheumatology (ACR) criteria for SLE and their disease severity was measured using Systemic Lupus Activity Measure (SLAM).
The "A" allele was found to be associated with increase in severity of SLE with the AA genotype present only in severe disease.
No association with SLE in general, compared to healthy subjects, was found with either dimorphism.
We also examined the transmission of haplotypes as defined by these polymorphisms.
The D and A alleles were found in strong linkage disequilibrium especially in severe SLE.
The DA-haplotype was more frequent in severe SLE, than mild to moderate disease.
Our findings suggest that DNA sequence variation in the ACE gene influences disease progression and severity of SLE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rabbani, Malik Hasan& Mahmud, M. Saeed& Mekan, Sabeen Fatima& Frossard, Philippe M.. 2008. Association of Angiotensin-converting enzyme gene dimorphisms with severity of lupus diseases. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 5, pp.761-766.
https://search.emarefa.net/detail/BIM-39719
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rabbani, Malik Hasan…[et al.]. Association of Angiotensin-converting enzyme gene dimorphisms with severity of lupus diseases. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 5 (Dec. 2008), pp.761-766.
https://search.emarefa.net/detail/BIM-39719
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rabbani, Malik Hasan& Mahmud, M. Saeed& Mekan, Sabeen Fatima& Frossard, Philippe M.. Association of Angiotensin-converting enzyme gene dimorphisms with severity of lupus diseases. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 5, pp.761-766.
https://search.emarefa.net/detail/BIM-39719
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 766
رقم السجل
BIM-39719
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر