Effect of antiviral therapy on hepatitis C virus related glomerulopathy
المؤلفون المشاركون
Abbas, Ghulam
Husayn, Shahid
Shafi, Tahir
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 19، العدد 5 (31 أكتوبر/تشرين الأول 2008)، ص ص. 775-780، 6ص.
الناشر
تاريخ النشر
2008-10-31
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
To determine the efficacy of antiviral therapy in hepatitis C virus associated glomerulopathy, we studied 30 patients with HCV-associated glomerulopathy at Sheikh Zayed Hospital, Lahore, Pakistan from June 2004 to February 2007.
Membranoproliferative glomerulonephritis (MPGN) was the commonest kidney lesion, being reported in 25 / 30 (83%), followed by membranous glomerulonephritis (MGN) in 3 / 30 (10%) and mesangioproliferative glomerulonephritis (MesGN) in 2 / 30 (7%).
Cryoglobulinaemia was positive in 8 / 20 (40%) cases.
Most common HCV genotype was 3a.
All the patients received interferon alpha combined with ribavirin therapy for 6-12 months based on viral genotypes and doses were adjusted according to renal function.
Anti-viral response was achieved in the form of aviremia at completion of 6 months treatment in 8 / 30 (26.6%), decreased transaminases levels from a mean of 96.4 ± 72.2 to 60.1 ± 44.3 IU / L, p= 0.005, 24-hour proteinuria decreased significantly from a mean of 4.8 g to 1.20 g, p= 0.001, and complement C3 and C4 concentrations returned to normal in those subjects who responded to treatment.
The rate of relapse was 50%.
We conclude that though the overall antiviral response of HCV was not high, there was a significant reduction in proteinuria suggesting indirectly an improvement in renal pathology.
Further studies with large number of patients with follow-up renal biopsies are warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abbas, Ghulam& Husayn, Shahid& Shafi, Tahir. 2008. Effect of antiviral therapy on hepatitis C virus related glomerulopathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 5, pp.775-780.
https://search.emarefa.net/detail/BIM-39725
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abbas, Ghulam…[et al.]. Effect of antiviral therapy on hepatitis C virus related glomerulopathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 5 (Dec. 2008), pp.775-780.
https://search.emarefa.net/detail/BIM-39725
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abbas, Ghulam& Husayn, Shahid& Shafi, Tahir. Effect of antiviral therapy on hepatitis C virus related glomerulopathy. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 5, pp.775-780.
https://search.emarefa.net/detail/BIM-39725
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 779-780
رقم السجل
BIM-39725
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر