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Cancer after renal transplantation : multicenter experience
المؤلفون المشاركون
Abd al-Rahim, Izz al-Din
Hachicha, Jamil
Sharaf al-Din, Khalid
Skhiri, Habib
Ashur, Abd al-Latif
al-May, Mezri
Khidr, Adil
Bin Abd Allah, Tayyib
Harz Allah, Qays
Yeich, Sumayyah
Belhadj, Rawdah
Younsi, Fathi
Manna, Jamil
Hamidah, Jalil
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 19، العدد 5 (31 أكتوبر/تشرين الأول 2008)، ص ص. 825-830، 6ص.
الناشر
تاريخ النشر
2008-10-31
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Renal transplant recipients are at higher risk of certain tumors such as lymphomas and skin cancers and then the general and dialysis populations.
We retrospectively studied the prevalence of tumors in adult renal transplant recipients in four Tunisian centers of transplantation in Tunis, Monsatir and Sfax from January 1986 to January 2005.
The study included 36 patients; 19 men and 17 women with a mean age of 34.6 years (range from 18-54 years).
The mean time since dialysis to transplantation was 43 months (6-131months).
Maintenance therapy was based on calcineurin inhibitors (CNI) in 86 % of cases, on antimetabolites and corticosteroids in 100 % of cases.
Anti-thymoglobulin was administered in a mean course of 12.4 days in 78 % of the patients.
Acute rejection occurred in 25 cases and was treated with polyclonal or monoclonal antibodies on 40 % of cases.
Incidence of cancer among our population was 7 % and occurred after a mean period of 54 months of transplantation (range from 4-160 months).
Eighty three percent of the tumors were solid, and the rest were in the skin.
Kaposi sarcoma formed 41.6 % and non-Hodgkin or Hodgkin lymphoma 27.7 % of the solid tumors, while spinocellular carcinoma formed 83% and basocellular carcinoma 17% of the skin tumors.
Switching CNI to sirolimus in 8.3% cases was associated with a favorable outcome.
Mortality was the outcome in 33.3% of the patients with cancer, while partial or complete regression of cancers was observed in 55.5% cases after decreasing the doses of the immunosuppressive medications.
We conclude that post renal transplant cancer is mainly characterized by the predominance of Kaposi sarcoma favored by solar exposure and rigorously induced and maintained immunosuppression.
Careful follow-up may results in early intervention and decrease mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Harz Allah, Qays& Abd al-Rahim, Izz al-Din& Sharaf al-Din, Khalid& Yeich, Sumayyah& Belhadj, Rawdah& Skhiri, Habib…[et al.]. 2008. Cancer after renal transplantation : multicenter experience. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 5, pp.825-830.
https://search.emarefa.net/detail/BIM-39860
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Harz Allah, Qays…[et al.]. Cancer after renal transplantation : multicenter experience. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 5 (Dec. 2008), pp.825-830.
https://search.emarefa.net/detail/BIM-39860
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Harz Allah, Qays& Abd al-Rahim, Izz al-Din& Sharaf al-Din, Khalid& Yeich, Sumayyah& Belhadj, Rawdah& Skhiri, Habib…[et al.]. Cancer after renal transplantation : multicenter experience. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 5, pp.825-830.
https://search.emarefa.net/detail/BIM-39860
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 828-830
رقم السجل
BIM-39860
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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