Synthesis and antibacterial evaluation of some new fused cyclic sulfoxides

الملخص EN

A series of diarylidine cyclohexanones (1t-12t) have been prepared via Clasien-Schmidt reaction then condensed with dimethyl sulphoxide through Michael-Claisen condensation to afford the corresponding fused heterocycles (13t-24t).

The structures of the products were elucidated by the spectrum (UV, IR, 1H-NMR).

The suggested mechanisms for these reactions were investigated according to theoretical calculations, heat of formation (H.

F.) and the steric energy (S.

E.).

Furthermore some of the products have been tested for their biological activity (antibacterial).