Renal tubular dysfunction with nephrocalcinosis in a patient with beta thalassemia minor
المؤلفون المشاركون
Jain, Manish
Chandrasekaran, Venkatraman
Indhumathi, Elayaperumal
Soundararajan, Periasamy
Prabahar, Murugesan Ram
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 19، العدد 6 (31 ديسمبر/كانون الأول 2008)، ص ص. 964-968، 5ص.
الناشر
تاريخ النشر
2008-12-31
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Thalassemia is a hereditary anemia resulting from defect in hemoglobin production.
Beta thalassemia is due to impaired production of beta globin chains, leading to a relative excess of alpha globin chains.
The term beta thalassemia minor is used to describe heterozygotes, who carry one normal beta globin allele and one beta thalassemic allele.
The vast majority of these patients are asymptomatic.
However, a variety of renal tubular abnormalities including hypercalciuria, hypomagnesemia with renal magnesium wasting, decreased tubular absorption of phosphorus, hypouricemia with renal uric acid wasting, renal glycosuria and tubular proteinuria have been described even in patients with beta thalassemia minor.
We here in report a 24-year old female patient who was found to have thalassemia minor and nephrocalcinosis with evidence of renal tubular dysfunction.
Investigations revealed normal renal function, hypercalciuria, reduced tubular reabsorption of phosphorus, hypomagnesemia and renal magnesium wasting.
Screening for aminoaciduria was found to be negative.
An acid loading test revealed normal urinary acidification.
Ultrasonogram of the abdomen revealed nephrocalcinosis and splenomegaly.
Detailed work up for anemia showed normal white cell and platelet count while peripheral smear showed microcytic hypochromic anemia with few target cells.
Hemoglobin electrophoresis revealed hemoglobin A of 92%, hemoglobin A2 of 6.2% and hemoglobin F of 1.8% consistent with beta thalassemia minor.
Her parental screening was normal.
A diagnosis of beta thalassemia minor with renal tubular dysfunction was made and the patient was started on thiazide diuretics to reduce hypercalciuria and advised regular follow-up.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prabahar, Murugesan Ram& Jain, Manish& Chandrasekaran, Venkatraman& Indhumathi, Elayaperumal& Soundararajan, Periasamy. 2008. Renal tubular dysfunction with nephrocalcinosis in a patient with beta thalassemia minor. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 6, pp.964-968.
https://search.emarefa.net/detail/BIM-40202
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prabahar, Murugesan Ram…[et al.]. Renal tubular dysfunction with nephrocalcinosis in a patient with beta thalassemia minor. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 6 (Dec. 2008), pp.964-968.
https://search.emarefa.net/detail/BIM-40202
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prabahar, Murugesan Ram& Jain, Manish& Chandrasekaran, Venkatraman& Indhumathi, Elayaperumal& Soundararajan, Periasamy. Renal tubular dysfunction with nephrocalcinosis in a patient with beta thalassemia minor. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 6, pp.964-968.
https://search.emarefa.net/detail/BIM-40202
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 967-968
رقم السجل
BIM-40202
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر