Effect of vitamin B1 2 on the activity of inhibited AChE

الملخص EN

Human serum AChE activity is measured in vitro using modified Ellman method and shows a wide range between (4.925-8.755) μmole/3min/ml.

The activity in men was higher than in women.

The possible medical importance of Vitamin B12 as a remover of the effects of poisonous and inhibiting compounds of AChE as possible substitute of Atropine was tested, the results showed that Vitamin B12 behaved as a reactivator, and the values of reactivation of both of Vitamin B12 and Atropine on the activity of'inhibited AChE by heterocyclic compounds sometimes appear approximately equal, these results lead to the conclusion that, it is possible to use Vitamin B12 instead of Atropine in treatment of poisoning caused by these types of inhibitors.

Mechanism of action of Vitamin B12 as reactivator was proposed.