Synthesis and characterization of some new heterocyclic compounds such as-oxadiazole and azetidine-2-one derivatives

الملخص EN

A series of four membered ring the azetidine-2-one 3 (a-c) have been synthesized via Schiff bases 2 (a-e) with derivative of acetic acid in the presence of triethylamine with phosphorusoxychloride using dry methylene chloride under inert nitrogen atmosphere at 0 °C.

To furnish the corresponding azetidine-2-one 3 (a-c) in moderate yields.

on the other hand aseries of five membered ring synthesized Substituted 1, 3, 4-oxadiazoles are of considerable pharmaceutical and material interest by treatment of a suspension of methyl salicyliate hydrazide (1) in ethanol reflux with hydrazine to give 2-hydroxybenzohydrazide (2) this compound treated with Carbon disulfide (CS2) in the presence of sodium hydroxide to give 2-mercapto-1, 3, 4,-Oxadiazole (3) this compound treated with hydrazine in ethanol to give 5-hydrazino-1, 3, 4-Oxadiazole (4).

Finally treatment of (4) with 2-bromobenzaldehyde to gave 1, 3, 4-Oxadiazole derivateives The structural of these compounds were monitored and confirmed by using spectroscopic tools as IR and 1HNMR spectra Elemental analysis.