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Effect of therapeutic dose of vitamin D on serum adiponectin and glycemia in vitamin D-insufficient or deficient type 2 diabetic Patients
المؤلفون المشاركون
Qurbani, Mustafa
Shadman, Zhalah
Baziar, Nima
Jafarian, Kurosh
Nikoo, Muhsin Khushniat
Abd Mishani, Mahshid
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 9 (30 سبتمبر/أيلول 2014)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2014-09-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الموضوعات
الملخص EN
Background : Lower vitamin D status has been reported in diabetic patients.
Serum 25-hydroxyvitamin D and adiponectin were inversely associated with type 2 diabetes and insulin resistance.
Vitamin D may involve in regulation of the adiponectin levels, which is directly related to insulin sensitivity. Objectives : The aim of this study was to investigate the effect of therapeutic dose of vitamin D on serum adiponectin and insulin resistance in vitamin D-insufficient or deficient type 2 diabetic patients. Materials and Methods : This double-blind, randomized, clinical trial was conducted on 81 type 2 diabetic patients with vitamin D level of 10-30 ng/mL.
Intervention was 50000 IU vitamin D or placebo once a week for 8 weeks.
At the beginning and end of the study, blood samples were collected after 12 hours of fasting and serum glucose, insulin, 25-hydroxyvitamin D, and adiponectin were measured.
Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Results : After 8-week intervention, serum 25-hydroxyvitamin D significantly increased and reached the normal levels in patients receiving vitamin D (P < 0.001) and the levels of fasting serum glucose, insulin, and HOMA-IR were significantly decreased (P = 0.04, 0.02 and 0.007, respectively).
No significant changes were observed in these levels in the placebo group.
Significant differences were observed in mean changes in the above-mentioned variables between the two groups (P = 0.01, 0.04 and 0.006, respectively).
No significant changes were found in serum adiponectin in the vitamin D and placebo groups (P = 0.83). Conclusions : Therapeutic dose of vitamin D can improve vitamin D status and glycemic indicators.
But it seems that an 8-week intervention period was not sufficient to reveal the possible effects of vitamin D on serum adiponectin levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baziar, Nima& Jafarian, Kurosh& Shadman, Zhalah& Qurbani, Mustafa& Nikoo, Muhsin Khushniat& Abd Mishani, Mahshid. 2014. Effect of therapeutic dose of vitamin D on serum adiponectin and glycemia in vitamin D-insufficient or deficient type 2 diabetic Patients. Iranian Red Crescent Medical Journal،Vol. 16, no. 9, pp.1-8.
https://search.emarefa.net/detail/BIM-408236
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baziar, Nima…[et al.]. Effect of therapeutic dose of vitamin D on serum adiponectin and glycemia in vitamin D-insufficient or deficient type 2 diabetic Patients. Iranian Red Crescent Medical Journal Vol. 16, no. 9 (Sep. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-408236
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baziar, Nima& Jafarian, Kurosh& Shadman, Zhalah& Qurbani, Mustafa& Nikoo, Muhsin Khushniat& Abd Mishani, Mahshid. Effect of therapeutic dose of vitamin D on serum adiponectin and glycemia in vitamin D-insufficient or deficient type 2 diabetic Patients. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 9, pp.1-8.
https://search.emarefa.net/detail/BIM-408236
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-408236
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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