Effect of therapeutic dose of vitamin D on serum adiponectin and glycemia in vitamin D-insufficient or deficient type 2 diabetic Patients
المؤلفون المشاركون
Qurbani, Mustafa
Shadman, Zhalah
Baziar, Nima
Jafarian, Kurosh
Nikoo, Muhsin Khushniat
Abd Mishani, Mahshid
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 9 (30 سبتمبر/أيلول 2014)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2014-09-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الموضوعات
الملخص EN
Background : Lower vitamin D status has been reported in diabetic patients.
Serum 25-hydroxyvitamin D and adiponectin were inversely associated with type 2 diabetes and insulin resistance.
Vitamin D may involve in regulation of the adiponectin levels, which is directly related to insulin sensitivity. Objectives : The aim of this study was to investigate the effect of therapeutic dose of vitamin D on serum adiponectin and insulin resistance in vitamin D-insufficient or deficient type 2 diabetic patients. Materials and Methods : This double-blind, randomized, clinical trial was conducted on 81 type 2 diabetic patients with vitamin D level of 10-30 ng/mL.
Intervention was 50000 IU vitamin D or placebo once a week for 8 weeks.
At the beginning and end of the study, blood samples were collected after 12 hours of fasting and serum glucose, insulin, 25-hydroxyvitamin D, and adiponectin were measured.
Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Results : After 8-week intervention, serum 25-hydroxyvitamin D significantly increased and reached the normal levels in patients receiving vitamin D (P < 0.001) and the levels of fasting serum glucose, insulin, and HOMA-IR were significantly decreased (P = 0.04, 0.02 and 0.007, respectively).
No significant changes were observed in these levels in the placebo group.
Significant differences were observed in mean changes in the above-mentioned variables between the two groups (P = 0.01, 0.04 and 0.006, respectively).
No significant changes were found in serum adiponectin in the vitamin D and placebo groups (P = 0.83). Conclusions : Therapeutic dose of vitamin D can improve vitamin D status and glycemic indicators.
But it seems that an 8-week intervention period was not sufficient to reveal the possible effects of vitamin D on serum adiponectin levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baziar, Nima& Jafarian, Kurosh& Shadman, Zhalah& Qurbani, Mustafa& Nikoo, Muhsin Khushniat& Abd Mishani, Mahshid. 2014. Effect of therapeutic dose of vitamin D on serum adiponectin and glycemia in vitamin D-insufficient or deficient type 2 diabetic Patients. Iranian Red Crescent Medical Journal،Vol. 16, no. 9, pp.1-8.
https://search.emarefa.net/detail/BIM-408236
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baziar, Nima…[et al.]. Effect of therapeutic dose of vitamin D on serum adiponectin and glycemia in vitamin D-insufficient or deficient type 2 diabetic Patients. Iranian Red Crescent Medical Journal Vol. 16, no. 9 (Sep. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-408236
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baziar, Nima& Jafarian, Kurosh& Shadman, Zhalah& Qurbani, Mustafa& Nikoo, Muhsin Khushniat& Abd Mishani, Mahshid. Effect of therapeutic dose of vitamin D on serum adiponectin and glycemia in vitamin D-insufficient or deficient type 2 diabetic Patients. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 9, pp.1-8.
https://search.emarefa.net/detail/BIM-408236
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-408236
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر