The effect of endometrial morphology and day 6th serum oestradiol concentrations on pregnancy outcomes in intracytoplasmic sperm injection (ICSI)‎ cycles using long GnRH agonist protocols

الملخص EN

ICSI is commonly used for treatment for infertility.

Significant Infertility affects up to one in seven couples all over the world.

Previous studies have demonstrated that poor uterine blood flow is a cause of infertility.

Embryo implantation depends on two processes : embryo quality, which seems most crucial, resulting in an embryo equipped for implantation and endometrial development, leading to uterine receptivity.

Endometrial receptivity depends on many biochemical and structural changes during the menstrual cycle.

Sonography represents one of the best non-invasive method which gives information about the pre- implantation prognosis by evaluation of the following parameters : morphological parameters (with bi dimensional sonography) as regard thickness and structure of the endometrium, functional parameters (with Doppler) as regard evaluation of uterine vascularisation as a marker of uterine receptivity.

Using sonography, hysteroscopy and endometrial biopsy we can learn about anatomical and functional markers of endometrial receptivity.

The aim of this prospective observational study is to assess the role of endometrial morphology (thickness and pattern) by TV ultrasound and serum E2 level on day 6th and its predictive value on pregnancy rate in ICSI cycle .It was designed for assessment of endometrial thickness and pattern and serum E2 level on day 6th of controlled ovarian hyperstimulation using long protocol in correlation to ICSI pregnancy rate among 50 infertile women undergoing ICSI attending the ART unit in IICPSR, Al-Azhar University.

Chemical pregnancy test was positive in 17 patients, non pregnant patients were 33.

Endometrial echo-pattern has good value in occurrence of pregnant cases where trilaminer endometrium has good pregnancy outcome.

Also there is no correlation between endometrial thickness and pregnancy rate.

There is correlation between high serum E2 level on day 6th and pregnancy rate in ICSI cycle.

We concluded that there is statistically significant correlated between E2 level on day 6th and ICSI outcomes.

Also endometrial pattern is statistically significant, but there is no significant correlation between endometrial thickness on day 6th and ICSI outcomes.