Androgenic-anabolic steroids abusing effect on liver enzymes and lipid profile in male and female rats

الملخص EN

The present study was conducted at Veterinary Medicine College-University of Basrha / Iraq to investigate the effect of testosterone ( Sustanon ® 250) abusing on some physiological and biochemical parameters.

Sixty four male and female rats were divided into four groups (each group consisted of 8 males and 8 females).

The first group served as control group in which the rats dosed by intramuscular injection with 10 μ l olive oil weekly for 12 weeks, the rest 3 treated groups (G1.

G2 and G3) in which the rats dosed by intramuscular injection with 50.

100 and 150 mg Sustanon ® 250 / kg B.

W.

respectively weekly for 12 weeks, then all rats were terminated for the physiological and biochemical tests .

The Sustanon ® 250 through its effect on liver caused increasing both ALT and AST and decreasing the ALP in treated rats compared with control group.

The lipid profile was significantly affected by Sustanon ® 250 injection through elevation of TG and VLDL, but lowering the HDL, LDL and AI.