DABCO promoted one-pot synthesis of dihydropyrano (c)‎ chromene and pyrano [2, 3-d] pyrimidine derivatives and their biological activities

الملخص EN

A simple and efficient one-pot synthesis of heteroaryl substititued dihydropyrano (c) chromenes and pyrano [2, 3-d] pyrimidines has been developed via initial Knoevenagel, subsequent Micheal and final heterocyclization reactions of heteroaryl aldehyde, malononitrile and barbituric acid / dimedone.

1, 4-Diazabicyclo [2.2.2] octane (DABCO) has been used as a catalyst.

Short reaction time, environment friendly procedure and excellent yields are the main advantages of this procedure.

All synthesized compounds have shown good antimicrobial activity against different microbial stains.