Evaluation of radioaprotective effect of certain leaves extracts of Inula viscosa on γ-irradiated male albino mice

العناوين الأخرى

تقييم الأثر الواقي للإشعاع لبعض مستخلصات أوراق الطيون لذكور الفئران المهقاء المعرضة لأشعة غاما

مقدم أطروحة جامعية

Abu Allush, Ward Khalid

مشرف أطروحة جامعية

al-Mansi, Kamal
Abu Sini, Majid

أعضاء اللجنة

Shakhanbeh, Jumah Muti
Abu Zaytun, Ahmad
Shunnaq, Isam

الجامعة

جامعة آل البيت

الكلية

كلية العلوم

القسم الأكاديمي

قسم العلوم الحياتية

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2012

الملخص الإنجليزي

Methodology: six groups of balb/c mice (12 mice/group) were involved in this study.

The first group was designed as control group without any treatment.

The second group was injected interaperitoneally with Inula viscosa extract(I.V.E.) (200mg/kg.b.wt.mouse).

The third group was exposed to 6 Gy (irradiated control group).

The fourth, fifth, and the last groups were treated by three doses of I.V.E.

(200, 400, and 800 mg/kg.b.wt.mice) interaperitonealy, then exposed to 6 Gy.

Results: In irradiated group, for the most biochemical parameters, irradiation induced significant changes in hematopoietic parameters, body weight, and stress oxidative markers of organ functions like (LPO and GSH).

Liver enzymes were elevated significantly compared with control group.

Hematological tests (Erythrocytes count, LeuKocytes count, hemoglobin concentration, and hematocrit value) were decreased significantly compared with control group.

LPO were increased significantly, and the GSH were decreased compared with control group.

While in the treated groups by three different doses of I.

viscosa (200, 400, and 800mg/kg) extracts, all previous parameters were restored significantly compared with control.

Biological damages in body organs were induced by exposed the whole body of animal to 60Co generator unit in Jordanian Atomic Energy Agency/Amman.

The treatment with I.V.E showed protective role, where all altered parameters restored significantly compared with irradiated control group.

Conclusion: the use of I.V.

leaves extract was proved to have significant effects in reducing the adverse effects of radiation poisoning.

From molecular and cellular point of view, the use of I.

viscosa needs to be more validated since adverse effects in terms of genotoxicity still forming risk factors especially in cancer therapy.

التخصصات الرئيسية

الأحياء

الموضوعات

• الفسيولوجيا
• النباتات الطبية
• الفئران

عدد الصفحات

85

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-416219