Immunohistochemical study of bone marrow angiogenesis in multiple myeloma and its correlation with clinicopathological factors
المؤلفون المشاركون
Jafar, Abd al-Karim M.
Buraid, Hasan A.
Naji, Rana Z.
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 56، العدد 2 (30 يونيو/حزيران 2014)، ص ص. 195-199، 5ص.
الناشر
تاريخ النشر
2014-06-30
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : In recent years, bone marrow angiogenesis was reported to be involved in the pathogenesis and progression of certain hematological malignancies like multiple myeloma, leukemias, and lymphomas.
Recent studies have suggested that bone marrow angiogenesis plays an important role in the pathogenesis and prognosis of multiple myeloma.
Objectives : at the present study, bone marrow angiogenesis in multiple myeloma was examined using immunohistochemical staining for CD34, and correlated with various pathological and clinical parameters.
Padents and methods : This is a retrospective study ; where by archival paraffin-embedded tissue blocks along with the clinical and hematological records of fifty-two patients with multiple myeloma and twenty controls were obtained from the Department of Hematology of the Medical City Teaching Laboratories in the period from January 2010 to January 2013.
Bone marrow angiogenesis was studied by immunohistochemical staining for CD34 to identify microvessels.
Results : There was a significant association between higher angiogenesis grades and advanced clinical stage of the disease (p = 0.002), and higher plasma cell percent in the bone marrow (p = 0.03), and increasing immaturity of the plasma cell (p = 0.001), and diffuse pattern of bone marrow infiltration by plasma cells (p = 0.007).
Conclusions : Patients with increased plasma cell burden, immature plasma cell morphology, and diffuse pattern of infiltration had a higher microvessel density.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Buraid, Hasan A.& Jafar, Abd al-Karim M.& Naji, Rana Z.. 2014. Immunohistochemical study of bone marrow angiogenesis in multiple myeloma and its correlation with clinicopathological factors. Journal of the Faculty of Medicine Baghdad،Vol. 56, no. 2, pp.195-199.
https://search.emarefa.net/detail/BIM-419494
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Buraid, Hasan A.…[et al.]. Immunohistochemical study of bone marrow angiogenesis in multiple myeloma and its correlation with clinicopathological factors. Journal of the Faculty of Medicine Baghdad Vol. 56, no. 2 (2014), pp.195-199.
https://search.emarefa.net/detail/BIM-419494
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Buraid, Hasan A.& Jafar, Abd al-Karim M.& Naji, Rana Z.. Immunohistochemical study of bone marrow angiogenesis in multiple myeloma and its correlation with clinicopathological factors. Journal of the Faculty of Medicine Baghdad. 2014. Vol. 56, no. 2, pp.195-199.
https://search.emarefa.net/detail/BIM-419494
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 199
رقم السجل
BIM-419494
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر