Pharmacological and antioxidant actions of garlic andor onion in non-alcoholic fatty liver disease (nafld) in rats
المؤلفون المشاركون
Hammam, Ulfat A.
Sayf al-Din, Sayyid H.
Sabra, Abd al-Nasir A.
Ubayd, Fatimah A.
al-Lakkany, Najla M.
المصدر
Journal of the Egyptian Society of Parasitology
العدد
المجلد 44، العدد 2 (31 أغسطس/آب 2014)، ص ص. 295-308، 14ص.
الناشر
الجمعية المصرية لعلم الطفيليات
تاريخ النشر
2014-08-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
Non-alcoholic fatty liver disease (NAFLD) includes a broad spectrum of fat-induced liver injury, ranging from mild steatosis to cirrhosis and liver failure.
This study investigates the hepatoprotective properties of garlic and onion in NAFLD rat model.
Ninety male Sprague- Dawley rats were randomly divided into 9 groups; normal (I), NAFLD induced with high fat diet (HFD; II), NAFLD switched to regular diet (RD; III), NAFLD-HFD or NAFLD-RD treated with garlic (IV, V), onion (VI, VII) or the combined garlic+onion (VIII, IX) respectively.
A NAFLD rat model was established by feeding the animals with a high-fat diet for 12 wk.
These animals were then treated with garlic or/and onion or vehicle for 8 wk (weeks 13-20) and then killed to obtain serum samples and liver tissues.
Liver histology, lipids, parameters of oxidative stress, TNF- and TGF- were measured.
The liver in NAFLD-HFD showed typical steatosis, accompanied with mild to moderate lobular inflammatory cell infiltration.
Serum levels of ALT, AST, ALP, leptin, cholesterol, triglycerides, TNF-α, TGF- and hepatic MDA were significantly increased (P<0.05) compared with normal group.
This was accompanied with reduction of hepatic GSH, GR, GPx, GST, SOD and serum adiponectin.
These changes were to a less degree in NAFLD-RD group.
Combined administration of garlic+onion produced a better and significant decrease in liver steatosis, serum liver enzymes, oxidative markers and lipid peroxidation versus each one alone.
In the same time, NAFLD-induced inflammation was also mitigated via reduction of TNF- and TGF-.
In addition, these results were better in the group IX versus group VIII.-
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sayf al-Din, Sayyid H.& Sabra, Abd al-Nasir A.& Hammam, Ulfat A.& Ubayd, Fatimah A.& al-Lakkany, Najla M.. 2014. Pharmacological and antioxidant actions of garlic andor onion in non-alcoholic fatty liver disease (nafld) in rats. Journal of the Egyptian Society of Parasitology،Vol. 44, no. 2, pp.295-308.
https://search.emarefa.net/detail/BIM-422357
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sayf al-Din, Sayyid H.…[et al.]. Pharmacological and antioxidant actions of garlic andor onion in non-alcoholic fatty liver disease (nafld) in rats. Journal of the Egyptian Society of Parasitology Vol. 44, no. 2 (Aug. 2014), pp.295-308.
https://search.emarefa.net/detail/BIM-422357
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sayf al-Din, Sayyid H.& Sabra, Abd al-Nasir A.& Hammam, Ulfat A.& Ubayd, Fatimah A.& al-Lakkany, Najla M.. Pharmacological and antioxidant actions of garlic andor onion in non-alcoholic fatty liver disease (nafld) in rats. Journal of the Egyptian Society of Parasitology. 2014. Vol. 44, no. 2, pp.295-308.
https://search.emarefa.net/detail/BIM-422357
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendices : p. 307-308
رقم السجل
BIM-422357
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر