Bile synthesis peculiarities following changes in the functional state of the endothelin receptors
المؤلفون المشاركون
Veselska, Nadiyah Stanislavovna
Ghazi, Sepideh Parchami
Yanchuk, Petro Ivanovich
Makarchuk, Nikolai Yukhimovich
المصدر
Jordan Journal of Biological Sciences
العدد
المجلد 7، العدد 4 (31 ديسمبر/كانون الأول 2014)، ص ص. 287-291، 5ص.
الناشر
الجامعة الهاشمية عمادة البحث العلمي و الدراسات العليا
تاريخ النشر
2014-12-31
دولة النشر
الأردن
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Endothelin-1(ET-1) regulates a variety of biochemical processes in liver.
However, there is no clear view concerning endothelin receptors participation in the regulation of qualitative and quantitative characteristics of liver secretory function.
The purpose of this study is to evaluate the choleretic effect of ET-1 and to determine the role of ЕТА receptors functional state in mediating the effect of ET-1 on bile and its organic components secretion.
Endothelin-1 and BQ-123 (cyclo-Asppro- Val-Leu-Trp) were intraportally injected.
Bile flow, bile acid concentration and content, hydroxylation and conjugation coefficients were estimated.
The results of this study showed that the secreted bile volume was decreased under the effect of endothelin-1and BQ-123, although this decrease was more prolonged and profound in BQ-123 treated animals.
Concentration of taurocholates, glycocholic acid and free bile acids was increased in the endothelin treated rats.
When BQ- 123 was administered, an increase in glycochenodeoxycholic acid+glycodeoxycholic acid (GCDCA+GDCA) and the taurin-conjugated bile acids concentration was found, whereas the free bile acids concentration altered reversely.
Coefficient of hydroxylation was diminished when entholelin receptors were blocked.
Activation of endothelin receptors by exogenous endothelin-1 intensified bile acids biosynthesis via “neutral pathway,”involving microsomal oxidation enzymes.
The present study concludes that the endothelin receptors blockade eliminated the regulatory function of endogenous endothelin and caused a shift in bile acids synthesis to mitochondrial enzymes through “acidic pathway”.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Veselska, Nadiyah Stanislavovna& Ghazi, Sepideh Parchami& Yanchuk, Petro Ivanovich& Makarchuk, Nikolai Yukhimovich. 2014. Bile synthesis peculiarities following changes in the functional state of the endothelin receptors. Jordan Journal of Biological Sciences،Vol. 7, no. 4, pp.287-291.
https://search.emarefa.net/detail/BIM-428571
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Veselska, Nadiyah Stanislavovna…[et al.]. Bile synthesis peculiarities following changes in the functional state of the endothelin receptors. Jordan Journal of Biological Sciences Vol. 7, no. 4 (Dec. 2014), pp.287-291.
https://search.emarefa.net/detail/BIM-428571
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Veselska, Nadiyah Stanislavovna& Ghazi, Sepideh Parchami& Yanchuk, Petro Ivanovich& Makarchuk, Nikolai Yukhimovich. Bile synthesis peculiarities following changes in the functional state of the endothelin receptors. Jordan Journal of Biological Sciences. 2014. Vol. 7, no. 4, pp.287-291.
https://search.emarefa.net/detail/BIM-428571
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 291
رقم السجل
BIM-428571
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر