Expression of cytokeratin 7, 20, 14 in urothelial carcinoma and squamous cell carcinoma of the Egyptian urinary bladder cancer
المؤلفون المشاركون
Badawi, Muhammad Ali
Wishahi, Muhammad
Hammam, Olfat
Khalil, Hibah
al-Janzuri, Husam
al-Khuli, Umar
al-Isaily, Khalid
المصدر
Journal of the Egyptian Society of Parasitology
العدد
المجلد 44، العدد 3 (31 ديسمبر/كانون الأول 2014)، ص ص. 733-740، 8ص.
الناشر
الجمعية المصرية لعلم الطفيليات
تاريخ النشر
2014-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
This study estimated the expression of CK-7, CK14, and CK-20 protein in human bladder carcinoma, urothelial carcinoma (UC) in comparison to squamous cell carcinoma (SCC) and to show its possible correlation to clinicopathologic parameters (grade and stage and bilharziasis), and investigate whether cytokeratin 14 immunostaining may be useful to detect early squamous metaplasia in bladder biopsies and in association with UC.
We evaluated the bladder tissues of 200 patients with bladder carcinoma, 150 patients had UC, and 50 patients had SCC.
Imunohistochemical technique was used for detection of CK7, CK14 and CK20 monoclonal ntibodies.
The mean age of the patients was 55 years (range51-70 years).
The UC were classified according to grades into grade I, II and III in 20, 40 and 90 cases, respectively.
Stages of UC were : Ta in 10, T1 in 60 and 90 patients with muscle-invasive T2-3.
In UC cases 105 / 150 (70 %) were positive for over expression of CK20.
In the same group of UC 120/150 (80) were positive for over expression of CK7.
Negative expression was found in SCC cases.
A High grades of the UC were associated with decrease expression of CK 20, there were 20 (100 %) in GI, 35 (87.5 %) in GII, 50 (68.6 %) in GIII (P < 0.01), and an increase expression of CK7 4 (20 %) in GI, 26 (65 %) in GII, 90(100 %) in GIII (P < 0.01).
CK20 expression decreased as the tumor stages increased, it was 15 (100 %) in Ta, 50 (83.3 %) in T1, 40 (50 %) in T2-3 (P < 0.01), while CK7 showed increase expression in 2 cases with Ta tumor (20 %), 38 (47.5 %) in T1, 80 (100 %) in T2-T3 (P < 0.01).
The present study confirmed that CK14 is expressed in SCC and in UC with squamous differentiation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hammam, Olfat& Wishahi, Muhammad& Khalil, Hibah& al-Janzuri, Husam& Badawi, Muhammad Ali& al-Khuli, Umar…[et al.]. 2014. Expression of cytokeratin 7, 20, 14 in urothelial carcinoma and squamous cell carcinoma of the Egyptian urinary bladder cancer. Journal of the Egyptian Society of Parasitology،Vol. 44, no. 3, pp.733-740.
https://search.emarefa.net/detail/BIM-430774
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hammam, Olfat…[et al.]. Expression of cytokeratin 7, 20, 14 in urothelial carcinoma and squamous cell carcinoma of the Egyptian urinary bladder cancer. Journal of the Egyptian Society of Parasitology Vol. 44, no. 3 (Dec. 2014), pp.733-740.
https://search.emarefa.net/detail/BIM-430774
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hammam, Olfat& Wishahi, Muhammad& Khalil, Hibah& al-Janzuri, Husam& Badawi, Muhammad Ali& al-Khuli, Umar…[et al.]. Expression of cytokeratin 7, 20, 14 in urothelial carcinoma and squamous cell carcinoma of the Egyptian urinary bladder cancer. Journal of the Egyptian Society of Parasitology. 2014. Vol. 44, no. 3, pp.733-740.
https://search.emarefa.net/detail/BIM-430774
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendices : p.739-740
رقم السجل
BIM-430774
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر