Can uremia and hemodialysis affect plasma levels of circulating TNF-α
المؤلفون المشاركون
Tuhami, Muhammad Ali
al-Minawy, Lubna
al-Karimi, Inas Ahmad Rida
Shahin, Faysal A. M.
al-Kussi, Muhsin Muhammad Husayn
Kamil, Nah
Shaykh, Iftikhar Ahmad
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 5، العدد 2 (30 يونيو/حزيران 1994)5ص.
الناشر
تاريخ النشر
1994-06-30
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
It is well known that uremia is associated with increased susceptibility to infection.
In addition, patients on hemodialysis (HD) experience a variety of dialysis associated complications, both acute and chronic, many of them having features similar to acute phase response.
Immunoregulatory cytokines such as tumor necrosis factor-a (TNF-a) have been implicated in the pathogenesis of immunological as well as inflammatory diseases.
Thus, TNF-a levels could be expected to be high in uremic patients as well as in HD patients.
We investigated the plasma levels of TNF-a in 17 patients with renal failure, seven patients with chronic renal failure (CRF) before commencement of HD and 10 patients maintained on regular HD.
Eight age matched healthy subjects were studied as normal control.
All CRF patients, who were not yet on dialysis, had high plasma levels of TNF-a (mean + SD 71.33 + 33.25 pg/ml).
Out of the HD group, TNF-a plasma levels were not detectable in five patients and in the remaining five, TNF-a plasma level (mean + SD 21.06 + 7.72) were comparable to the normal controls (mean + SD 21 + 7.87).
Our findings suggest that factors related to uremia, but not to HD, are responsible for high TNF-a plasma levels in these patients and that, HD probably has a beneficial effect by removal and/or neutralising of uremic toxins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Kussi, Muhsin Muhammad Husayn& al-Minawy, Lubna& Kamil, Nah& al-Karimi, Inas Ahmad Rida& Tuhami, Muhammad Ali& Shaykh, Iftikhar Ahmad…[et al.]. 1994. Can uremia and hemodialysis affect plasma levels of circulating TNF-α. Saudi Journal of Kidney Diseases and Transplantation،Vol. 5, no. 2.
https://search.emarefa.net/detail/BIM-433393
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Kussi, Muhsin Muhammad Husayn…[et al.]. Can uremia and hemodialysis affect plasma levels of circulating TNF-α. Saudi Journal of Kidney Diseases and Transplantation Vol. 5, no. 2 (1994).
https://search.emarefa.net/detail/BIM-433393
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Kussi, Muhsin Muhammad Husayn& al-Minawy, Lubna& Kamil, Nah& al-Karimi, Inas Ahmad Rida& Tuhami, Muhammad Ali& Shaykh, Iftikhar Ahmad…[et al.]. Can uremia and hemodialysis affect plasma levels of circulating TNF-α. Saudi Journal of Kidney Diseases and Transplantation. 1994. Vol. 5, no. 2.
https://search.emarefa.net/detail/BIM-433393
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-433393
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر