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Haematological, biochemical and histopathological alterations induced by ivermectin in donkeys (Equus asinus)
المؤلفون المشاركون
Ismail, Nihal H. A.
Bulldan, Ahmad Jafar Ahmad
Sulayman, Siham Ilyas
Siri, Hisham Ismail
المصدر
Sudan Journal of Science and Technology
العدد
المجلد 14، العدد 2 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
جامعة السودان للعلوم و التكنولوجيا عمادة البحث العلمي
تاريخ النشر
2013-12-31
دولة النشر
السودان
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
The current study was conducted to assess the pharmacotoxic effects of repeated administration of Ivermectin (Intermectin 1 %) injection formulation in male donkeys.
The various haematological, biochemical parameters and histopathological changes were noted.
Two groups each of six of male donkeys were utilized in the current investigation.
Following fasting for 48 hours, Ivermectin was administered subcutaneously at the neck region either at the recommended dose level 200 µg / kg (T1) or at 5 times the recommended dose.
1000 µg / kg (T2) body weight for seven successive days to one of the groups, respectively.
Ivermectin was found to pose risks of renal and hepato-toxicity in donkeys, since the biochemical parameters of liver function (aspartate aminotransferase "AST" activity, alanine aminotransferase activity "ALT") and kidney function (urea concentration) were severely affected.
Changes in biochemical parameters were more intense in donkeys from group T2 than those reported in group T1.
Four animals out of six died following treatment in group T2.
The level of ALT, AST, and urea were significantly elevated in donkeys from group T2 when compared to the pretreatment values.
Post-mortem and histopathological examination ensured biochemical alterations of liver and kidneys.
Likewise, some haematological indices : erythrocyte count, leukocyte count, haemoglobin concentration and PCV, were also influenced.
In conclusion the repeated administration of Ivermectin injection formulation at five times the recommended dose is fatal to donkeys.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ismail, Nihal H. A.& Sulayman, Siham Ilyas& Bulldan, Ahmad Jafar Ahmad& Siri, Hisham Ismail. 2013. Haematological, biochemical and histopathological alterations induced by ivermectin in donkeys (Equus asinus). Sudan Journal of Science and Technology،Vol. 14, no. 2, pp.1-14.
https://search.emarefa.net/detail/BIM-435246
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ismail, Nihal H. A.…[et al.]. Haematological, biochemical and histopathological alterations induced by ivermectin in donkeys (Equus asinus). Sudan Journal of Science and Technology Vol. 14, no. 2 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-435246
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ismail, Nihal H. A.& Sulayman, Siham Ilyas& Bulldan, Ahmad Jafar Ahmad& Siri, Hisham Ismail. Haematological, biochemical and histopathological alterations induced by ivermectin in donkeys (Equus asinus). Sudan Journal of Science and Technology. 2013. Vol. 14, no. 2, pp.1-14.
https://search.emarefa.net/detail/BIM-435246
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 11-14
رقم السجل
BIM-435246
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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