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Antidepressant-like effect of resveratrol in a subchronic model of depression
المؤلفون المشاركون
Abd Allah, Hibah M. I.
Abd al-Rahman, Rihab F.
Ahmad, Raniya F.
Salih, Dalia O.
Farid, Umar A. H. A.
Husayn, Alya F.
المصدر
Journal of the Arab Society for Medical Research
العدد
المجلد 9، العدد 2 (31 ديسمبر/كانون الأول 2014)، ص ص. 48-53، 6ص.
الناشر
تاريخ النشر
2014-12-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background and aim : Depression is one of the most serious and common mental diseases with major negative social consequences.
Transresveratrol (trans-3, 5, 4´-trihydroxystilbene) is a polyphenolic compound with a broad spectrum of pharmacological activities.
It has been detected in some fruits and herbs, including the Asian plant Polygonum cuspidatum.
The aim of this study was to assess the antidepressant-like effect of transresveratrol in a reserpine subchronic model of depression.
Materials and methods : Depression-like behaviours were induced in rats by reserpine injection (0.25 mg / kg, subcutaneously) every 48 h, for 20 days.
Transresveratrol (60 and 120 mg / kg) and fl uoxetine (10 mg / kg) were administered orally daily during the 20 days of the study.
Behavioural tests, namely, open-field test and forced swimming test, as well as brain neurotransmitters levels and antioxidant contents and liver functions, were assessed.
Results : Data revealed that transresveratrol improved the rats’ behaviour in both the open-field test and forced swimming test, and also elevated the brain’s neurotransmitter content, normalized the liver enzymes level, and improved the antioxidant status of both the brain and liver, compared with those of fluoxetine.
Conclusion : The present study provided a clear evidence for the antidepressant-like of transresveratrol in the experimental model of depression.
Further investigations are required to investigate the mechanism of action of transresveratrol as well as its applicability to be used as an antidepressant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad, Raniya F.& Abd al-Rahman, Rihab F.& Abd Allah, Hibah M. I.& Salih, Dalia O.& Farid, Umar A. H. A.& Husayn, Alya F.. 2014. Antidepressant-like effect of resveratrol in a subchronic model of depression. Journal of the Arab Society for Medical Research،Vol. 9, no. 2, pp.48-53.
https://search.emarefa.net/detail/BIM-436436
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad, Raniya F.…[et al.]. Antidepressant-like effect of resveratrol in a subchronic model of depression. Journal of the Arab Society for Medical Research Vol. 9, no. 2 (2014), pp.48-53.
https://search.emarefa.net/detail/BIM-436436
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad, Raniya F.& Abd al-Rahman, Rihab F.& Abd Allah, Hibah M. I.& Salih, Dalia O.& Farid, Umar A. H. A.& Husayn, Alya F.. Antidepressant-like effect of resveratrol in a subchronic model of depression. Journal of the Arab Society for Medical Research. 2014. Vol. 9, no. 2, pp.48-53.
https://search.emarefa.net/detail/BIM-436436
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 52-53
رقم السجل
BIM-436436
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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