Coenzyme Q10 administration in community-acquired pneumonia in the elderly
المؤلفون المشاركون
Farazi, Aliasghar
Sufyan, Masoomeh
Jabbariasl, Mansoureh
Nayebzadeh, Banafshe
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 12 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
تاريخ النشر
2014-12-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Community-acquired pneumonia (CAP) is generally considered a major cause of morbidity and mortality in the elderly.
Objectives : This study aimed to assess the efficacy of adjunctive coenzyme Q10 (CoQ10) in the treatment of elderly CAP.
Patients and Methods: Hospitalized elderly patients with CAP (diagnosed by using defined clinical and radiological criteria) were randomized to receive oral CoQ10 (200 mg/d) or placebo for 14 days, along with antibiotics.
Primary and secondary outcomes on days 3, 7, and 14 were measured.
Disease severity was scored using CURB-65 index.
Statistical analysis was performed using SPSS and P value < 0.05 was considered significant.
Results : We enrolled 150 patients for this research.
Then, 141 patients, including 70 patients in the trial group and 71 patients in the control group were analyzed.
Mean age of the trial and control groups were 67.6 ± 7.2 years and 68.7 ± 7.9 years, respectively.
Clinical cure at days 3 and 7 were 24 (34.3%) and 62 (88.6%) in the trial group (P value = 0.6745) and 22 (31%) and 52 (73.2 %) in the placebo group (P value = 0.0209).
Patients on CoQ10 had faster defervescence (P value = 0.0206) and shorter hospital stay (P value = 0.0144) compared with the placebo group.
The subgroup analysis of the patients with severe pneumonia showed differences in clinical cure at day 14.
Treatment failure was less in CoQ10 group than in the placebo group (10 % versus 22.5 % and P value = 0.0440).
Adverse events in two groups were few and similar.
Conclusions: CoQ10 administration has no serious side effects and can improve outcome in hospitalized elderly CAP; therefore, we recommend it as an adjunctive treatment in elderly patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Farazi, Aliasghar& Sufyan, Masoomeh& Jabbariasl, Mansoureh& Nayebzadeh, Banafshe. 2014. Coenzyme Q10 administration in community-acquired pneumonia in the elderly. Iranian Red Crescent Medical Journal،Vol. 16, no. 12, pp.1-7.
https://search.emarefa.net/detail/BIM-441945
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Farazi, Aliasghar…[et al.]. Coenzyme Q10 administration in community-acquired pneumonia in the elderly. Iranian Red Crescent Medical Journal Vol. 16, no. 12 (Dec. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-441945
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Farazi, Aliasghar& Sufyan, Masoomeh& Jabbariasl, Mansoureh& Nayebzadeh, Banafshe. Coenzyme Q10 administration in community-acquired pneumonia in the elderly. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 12, pp.1-7.
https://search.emarefa.net/detail/BIM-441945
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6-7
رقم السجل
BIM-441945
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر