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Focal and segmental glomerulosclerosis : Does prognosis vary With the variants?
المؤلفون المشاركون
Ram, R.
Dakshinamurty, K. V.
Sahay, Manisha
Swarnalatha, Guditi
Ismal, Kiran Mai
Vali, Sharmas
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 26، العدد 1 (28 فبراير/شباط 2015)، ص ص. 173-181، 9ص.
الناشر
تاريخ النشر
2015-02-28
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Focal and segmental glomerulosclerosis (FSGS) is a clinicopathological entity.
The following five FSGS variants: Collapsing, cellular, glomerular tip, peri-hilar and not otherwise specified (NOS) are recognized, which may have prognostic value.
The aim of this study was to highlight the clinical course and outcome in the different pathological variants of FSGS and to evaluate the predictive risk factors of end-stage renal disease (ESRD).
It was a retrospective analysis of biopsy-proven primary FSGS patients who presented over a period of three years.
The data were collected from the clinical and biopsy records of the Nephrology Unit.
There were 116 patients with biopsy-proven FSGS.
The frequency of occurrence of FSGS among all cases of the nephrotic syndrome seen in our unit was 35.47%.
NOS was the most common pathological variant (62.2 %), followed by peri-hilar (11.2%), cellular (9.4%) and glomerular tip (7.7%), and the least common variant was collapsing (4.3 %).
Majority of patients with collapsing, NOS and glomerular tip variants had nephrotic range proteinuria.
However, the amount of proteinuria was highest in the glomerular tip and collapsing variants.
A higher percentage of patients with the collapsing and cellular variants had renal failure at the time of presentation.
A higher rate of tubular and interstitial changes was seen in the collapsing and cellular variants.
The collapsing and cellular variants showed lower response rate and higher rates of ESRD, while the glomerular tip lesion had the highest remission rate and the lowest rate of ESRD.
Poor prognostic factors for ESRD in FSGS were initial renal insufficiency, severe tubulo-interstitial change, initial nonresponsiveness to steroids and collapsing histopathological variant.
Our study suggests that histopathological classification of FSGS is of paramount importance in the management and in predicting the prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Swarnalatha, Guditi& Ram, R.& Ismal, Kiran Mai& Vali, Sharmas& Sahay, Manisha& Dakshinamurty, K. V.. 2015. Focal and segmental glomerulosclerosis : Does prognosis vary With the variants?. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 1, pp.173-181.
https://search.emarefa.net/detail/BIM-442562
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Swarnalatha, Guditi…[et al.]. Focal and segmental glomerulosclerosis : Does prognosis vary With the variants?. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 1 (Jan. / Feb. 2015), pp.173-181.
https://search.emarefa.net/detail/BIM-442562
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Swarnalatha, Guditi& Ram, R.& Ismal, Kiran Mai& Vali, Sharmas& Sahay, Manisha& Dakshinamurty, K. V.. Focal and segmental glomerulosclerosis : Does prognosis vary With the variants?. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 1, pp.173-181.
https://search.emarefa.net/detail/BIM-442562
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 180-181
رقم السجل
BIM-442562
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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