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Flavonoid Naringenin : A Potential Immunomodulator for Chlamydia trachomatis Inflammation
المؤلفون المشاركون
Yilma, Abebayehu N.
Dennis, Vida A.
Morici, Lisa
Singh, Shree Ram
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Chlamydia trachomatis, the agent of bacterial sexually transmitted infections, can manifest itself as either acute cervicitis, pelvic inflammatory disease, or a chronic asymptomatic infection.
Inflammation induced by C.
trachomatis contributes greatly to the pathogenesis of disease.
Here we evaluated the anti-inflammatory capacity of naringenin, a polyphenolic compound, to modulate inflammatory mediators produced by mouse J774 macrophages infected with live C.
trachomatis.
Infected macrophages produced a broad spectrum of inflammatory cytokines (GM-CSF, TNF, IL-1β, IL-1α, IL-6, IL-12p70, and IL-10) and chemokines (CCL4, CCL5, CXCL1, CXCL5, and CXCL10) which were downregulated by naringenin in a dose-dependent manner.
Enhanced protein and mRNA gene transcript expressions of TLR2 and TLR4 in addition to the CD86 costimulatory molecule on infected macrophages were modulated by naringenin.
Pathway-specific inhibition studies disclosed that p38 mitogen-activated-protein kinase (MAPK) is involved in the production of inflammatory mediators by infected macrophages.
Notably, naringenin inhibited the ability of C.
trachomatis to phosphorylate p38 in macrophages, suggesting a potential mechanism of its attenuation of concomitantly produced inflammatory mediators.
Our data demonstrates that naringenin is an immunomodulator of inflammation triggered by C.
trachomatis, which possibly may be mediated upstream by modulation of TLR2, TLR4, and CD86 receptors on infected macrophages and downstream via the p38 MAPK pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yilma, Abebayehu N.& Singh, Shree Ram& Morici, Lisa& Dennis, Vida A.. 2013. Flavonoid Naringenin : A Potential Immunomodulator for Chlamydia trachomatis Inflammation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-446465
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yilma, Abebayehu N.…[et al.]. Flavonoid Naringenin : A Potential Immunomodulator for Chlamydia trachomatis Inflammation. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-446465
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yilma, Abebayehu N.& Singh, Shree Ram& Morici, Lisa& Dennis, Vida A.. Flavonoid Naringenin : A Potential Immunomodulator for Chlamydia trachomatis Inflammation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-446465
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-446465
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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