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Once Daily Valacyclovir for Reducing Viral Shedding in Subjects Newly Diagnosed with Genital Herpes
المؤلفون المشاركون
Brennan, Clare A.
Martens, Mark G.
Dix, Lynn P.
Leone, Peter A.
Fife, Kenneth H.
المصدر
Infectious Diseases in Obstetrics and Gynecology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-08-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Genital herpes (GH) recurrences and viral shedding are more frequent in the first year after initial HSV-2 infection.
The objective of this study was to provide the first evaluation of valacyclovir 1 g once daily compared to placebo in reducing viral shedding in subjects newly diagnosed with GH.
Methods.
70 subjects were randomized to receive valacyclovir 1 g daily or placebo in a crossover design for 60 days with a 7-day washout period.
A daily swab of the genital/anal-rectal area was self-collected for HSV-2 detection by PCR.
Subjects attended the clinic for routine study visits and GH recurrence visits.
Treatment differences were assessed using a nonparametric crossover analysis.
Results.
52 subjects had at least one PCR measurement in both treatment periods and comprised the primary efficacy population.
Valacyclovir significantly reduced HSV-2 shedding during all days compared to placebo (mean 2.9% versus 13.5% of all days (P<.01), a 78% reduction).
Valacyclovir significantly reduced subclinical HSV-2 shedding during all days compared to placebo (mean 2.4% versus 11.0% of all days (P<.01), a 78% reduction).
However, 79% of subjects had no GH recurrences while receiving valacyclovir compared to 52% of subjects receiving placebo (P<.01).
Conclusion.
In this study, the frequency of total and subclinical HSV-2 shedding was greater than reported in earlier studies involving subjects with a history of symptomatic genital recurrences.
Our study is the first to demonstrate a significant reduction in viral shedding with valacyclovir 1 g daily compared to placebo in a population of subjects newly diagnosed with HSV-2 infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Martens, Mark G.& Fife, Kenneth H.& Leone, Peter A.& Dix, Lynn P.& Brennan, Clare A.. 2009. Once Daily Valacyclovir for Reducing Viral Shedding in Subjects Newly Diagnosed with Genital Herpes. Infectious Diseases in Obstetrics and Gynecology،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-446767
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Martens, Mark G.…[et al.]. Once Daily Valacyclovir for Reducing Viral Shedding in Subjects Newly Diagnosed with Genital Herpes. Infectious Diseases in Obstetrics and Gynecology No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-446767
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Martens, Mark G.& Fife, Kenneth H.& Leone, Peter A.& Dix, Lynn P.& Brennan, Clare A.. Once Daily Valacyclovir for Reducing Viral Shedding in Subjects Newly Diagnosed with Genital Herpes. Infectious Diseases in Obstetrics and Gynecology. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-446767
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-446767
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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