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Mouse Ficolin B Has an Ability to Form Complexes with Mannose-Binding Lectin-Associated Serine Proteases and Activate Complement through the Lectin Pathway
المؤلفون المشاركون
Takahashi, Minoru
Endo, Yuichi
Ishida, Yumi
Fujita, Teizo
Iwaki, Daisuke
Matsushita, Misao
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Ficolins are thought to be pathogen-associated-molecular-pattern-(PAMP-) recognition molecules that function to support innate immunity.
Like mannose-binding lectins (MBLs), most mammalian ficolins form complexes with MBL-associated serine proteases (MASPs), leading to complement activation via the lectin pathway.
However, the ability of murine ficolin B, a homologue of human M-ficolin, to perform this function is still controversial.
The results of the present study show that ficolin B in mouse bone marrow is an oligomeric protein.
Ficolin B, pulled down using GlcNAc-agarose, contained very low, but detectable, amounts of MASP-2 and small MBL-associated protein (sMAP) and showed detectable C4-deposition activity on immobilized N-acetylglucosamine.
These biochemical features of ficolin B were confirmed using recombinant mouse ficolin B produced in CHO cells.
Taken together, these results suggest that like other mammalian homologues, murine ficolin B has an ability to exert its function via the lectin pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Endo, Yuichi& Iwaki, Daisuke& Ishida, Yumi& Takahashi, Minoru& Matsushita, Misao& Fujita, Teizo. 2012. Mouse Ficolin B Has an Ability to Form Complexes with Mannose-Binding Lectin-Associated Serine Proteases and Activate Complement through the Lectin Pathway. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-446807
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Endo, Yuichi…[et al.]. Mouse Ficolin B Has an Ability to Form Complexes with Mannose-Binding Lectin-Associated Serine Proteases and Activate Complement through the Lectin Pathway. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-446807
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Endo, Yuichi& Iwaki, Daisuke& Ishida, Yumi& Takahashi, Minoru& Matsushita, Misao& Fujita, Teizo. Mouse Ficolin B Has an Ability to Form Complexes with Mannose-Binding Lectin-Associated Serine Proteases and Activate Complement through the Lectin Pathway. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-446807
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-446807
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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