The Impact of Nanochloroquine on Restoration of Hepatic and Splenic Mitochondrial Damage against Rodent Malaria

المؤلفون المشاركون

Roy, Somenath
Dash, Sandeep Kumar
Tripathy, Satyajit
Chattopadhyay, Sourav
Das, Sabyasachi

المصدر

Journal of Nanoparticles

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-05-16

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

العلوم الهندسية و تكنولوجيا المعلومات
الكيمياء

الملخص EN

The applications of nanotechnology to pharmacology are the potential appliance of biodegradable polymers and convection-enhanced drug delivery in the diagnostics and treatment of diseases.

Chitosan is a natural polysaccharide that has attracted significant scientific interest during the last two decades.

The present study was to evaluate the possible effects of chitosan tripolyphosphate conjugated nanochloroquine against Plasmodium berghei infection on select makers of oxidative damage and antioxidant status in mitochondria of liver and spleen.

P.

berghei infection was developed in Swiss mice by intraperitoneal injection of 200 µL of infected blood.

Parasite-infected mice were treated with chloroquine and nanoconjugated chloroquine.

Superoxide radical generation, nitrate level, and oxidized glutathione were increased significantly (P<0.05) in the mitochondria of infected group as compared to control group, and reduced glutathione level, activity of SOD, GPx, GR, and GST, and mitochondrial transmembrane potential were decreased significantly (P<0.05), which were increased or decreased significantly (P<0.05) near to normal in nanoconjugated chloroquine treated group than chloroquine treated group.

So, the findings may suggest the advantageous role of nanoconjugated chloroquine against the P.

berghei induced oxidative damage in hepatic and splenic mitochondria.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Tripathy, Satyajit& Das, Sabyasachi& Dash, Sandeep Kumar& Chattopadhyay, Sourav& Roy, Somenath. 2013. The Impact of Nanochloroquine on Restoration of Hepatic and Splenic Mitochondrial Damage against Rodent Malaria. Journal of Nanoparticles،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-446838

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Tripathy, Satyajit…[et al.]. The Impact of Nanochloroquine on Restoration of Hepatic and Splenic Mitochondrial Damage against Rodent Malaria. Journal of Nanoparticles No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-446838

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Tripathy, Satyajit& Das, Sabyasachi& Dash, Sandeep Kumar& Chattopadhyay, Sourav& Roy, Somenath. The Impact of Nanochloroquine on Restoration of Hepatic and Splenic Mitochondrial Damage against Rodent Malaria. Journal of Nanoparticles. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-446838

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-446838