The Impact of Nanochloroquine on Restoration of Hepatic and Splenic Mitochondrial Damage against Rodent Malaria
المؤلفون المشاركون
Roy, Somenath
Dash, Sandeep Kumar
Tripathy, Satyajit
Chattopadhyay, Sourav
Das, Sabyasachi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الهندسية و تكنولوجيا المعلومات
الكيمياء
الملخص EN
The applications of nanotechnology to pharmacology are the potential appliance of biodegradable polymers and convection-enhanced drug delivery in the diagnostics and treatment of diseases.
Chitosan is a natural polysaccharide that has attracted significant scientific interest during the last two decades.
The present study was to evaluate the possible effects of chitosan tripolyphosphate conjugated nanochloroquine against Plasmodium berghei infection on select makers of oxidative damage and antioxidant status in mitochondria of liver and spleen.
P.
berghei infection was developed in Swiss mice by intraperitoneal injection of 200 µL of infected blood.
Parasite-infected mice were treated with chloroquine and nanoconjugated chloroquine.
Superoxide radical generation, nitrate level, and oxidized glutathione were increased significantly (P<0.05) in the mitochondria of infected group as compared to control group, and reduced glutathione level, activity of SOD, GPx, GR, and GST, and mitochondrial transmembrane potential were decreased significantly (P<0.05), which were increased or decreased significantly (P<0.05) near to normal in nanoconjugated chloroquine treated group than chloroquine treated group.
So, the findings may suggest the advantageous role of nanoconjugated chloroquine against the P.
berghei induced oxidative damage in hepatic and splenic mitochondria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tripathy, Satyajit& Das, Sabyasachi& Dash, Sandeep Kumar& Chattopadhyay, Sourav& Roy, Somenath. 2013. The Impact of Nanochloroquine on Restoration of Hepatic and Splenic Mitochondrial Damage against Rodent Malaria. Journal of Nanoparticles،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-446838
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tripathy, Satyajit…[et al.]. The Impact of Nanochloroquine on Restoration of Hepatic and Splenic Mitochondrial Damage against Rodent Malaria. Journal of Nanoparticles No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-446838
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tripathy, Satyajit& Das, Sabyasachi& Dash, Sandeep Kumar& Chattopadhyay, Sourav& Roy, Somenath. The Impact of Nanochloroquine on Restoration of Hepatic and Splenic Mitochondrial Damage against Rodent Malaria. Journal of Nanoparticles. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-446838
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-446838
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر