![](/images/graphics-bg.png)
A Prospective, Multinational Pharmacoepidemiological Study of Clinical Conversion to Sirolimus Immunosuppression after Renal Transplantation
المؤلفون المشاركون
Campistol, Josep
Del Carmen Rial, Maria
Russ, Graeme
Raffaele, Pablo
Nashan, Bjorn
Keown, Paul A.
Kasiske, Bertram L.
Pescovitz, Mark D.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-09
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
This prospective pharmacoepidemiological study examined treatment and outcomes in patients converted to sirolimus (SRL) after renal transplantation.
484 subjects in 36 centres in 7 countries were followed for up to 5 years.
Principal reasons for conversion were declining graft function (146/484, 30%) and side effects of prior therapy (144/484, 30%) and the major treatment combinations after conversion were SRL ± MMF (62%), SRL + TAC (21.5%), SRL + CSA (16.5%).
The cumulative probability of biopsy-confirmed acute rejection (BCAR) was 5% (n=22), death-censored graft loss 12% (n=56) and death 6% (n=22), and there was no significant relationship to the treatment combination employed.
Median calculated creatinine clearance was 48.4 (29.3, 64.5) mL/min at conversion, rising to 54.1 (41.2, 69.0) mL/min at month 1, 55.7 (39.0, 73.0) mL/min at month 12, 58.6 (39.7, 75.2) mL/min at two years and 60.9 (36.0, 77.0) mL/min at three years post-conversion.
The most common adverse events were hypertension (47%), hyperlipidemia (26%), urinary tract infections (25%), anaemia (24%) and diarrhea (14%), and cardiac events, hyperlipemia and CMV infection were more common in patients converted during the first year.
SRL was most frequently combined with MMF after conversion, but principal clinical outcomes were not significantly influenced by the treatment combination employed in normal practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kasiske, Bertram L.& Nashan, Bjorn& Del Carmen Rial, Maria& Raffaele, Pablo& Russ, Graeme& Campistol, Josep…[et al.]. 2012. A Prospective, Multinational Pharmacoepidemiological Study of Clinical Conversion to Sirolimus Immunosuppression after Renal Transplantation. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-446942
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kasiske, Bertram L.…[et al.]. A Prospective, Multinational Pharmacoepidemiological Study of Clinical Conversion to Sirolimus Immunosuppression after Renal Transplantation. Journal of Transplantation No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-446942
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kasiske, Bertram L.& Nashan, Bjorn& Del Carmen Rial, Maria& Raffaele, Pablo& Russ, Graeme& Campistol, Josep…[et al.]. A Prospective, Multinational Pharmacoepidemiological Study of Clinical Conversion to Sirolimus Immunosuppression after Renal Transplantation. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-446942
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-446942
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)