Short-Term Exercise Training Improves Insulin Sensitivity but Does Not Inhibit Inflammatory Pathways in Immune Cells from Insulin-Resistant Subjects
المؤلفون المشاركون
Cersosimo, Eugenio
Tantiwong, Puntip
DeFronzo, Ralph A.
Sriwijitkamol, Apiradee
Musi, Nicolas
Reyna, Sara M.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Exercise has an anti-inflammatory effect against, and immune cells play critical roles in the development, of insulin resistance and atherosclerotic vascular disease (AVD).
Thus, the goal of this study was to determine whether exercise improves insulin sensitivity in insulin-resistant subjects by downregulating proinflammatory signaling in immune cells.
Methods.
Seventeen lean, 8 obese nondiabetic, and 11 obese type 2 diabetic individuals underwent an aerobic exercise program for 15 days and an insulin clamp before and after exercise.
Peripheral mononuclear cells (PMNC) were obtained for determination of Toll-like receptor (TLR) 2 and 4 protein content and mitogen-activated protein kinase phosphorylation.
Results.
Compared with that in lean individuals, TLR4 protein content was increased by 4.2-fold in diabetic subjects.
This increase in TLR4 content was accompanied by a 3.0-fold increase in extracellular signal-regulated kinase (ERK) phosphorylation.
Exercise improved insulin sensitivity in the lean, obese, and type 2 diabetes groups.
However, exercise did not affect TLR content or ERK phosphorylation.
Conclusions.
TLR4 content and ERK phosphorylation are increased in PMNC of type 2 diabetic individuals.
While exercise improves insulin sensitivity, this effect is not related to changes in TLR2/TLR4 content or ERK phosphorylation in PMNC of type 2 diabetic individuals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reyna, Sara M.& Tantiwong, Puntip& Cersosimo, Eugenio& DeFronzo, Ralph A.& Sriwijitkamol, Apiradee& Musi, Nicolas. 2013. Short-Term Exercise Training Improves Insulin Sensitivity but Does Not Inhibit Inflammatory Pathways in Immune Cells from Insulin-Resistant Subjects. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-446996
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reyna, Sara M.…[et al.]. Short-Term Exercise Training Improves Insulin Sensitivity but Does Not Inhibit Inflammatory Pathways in Immune Cells from Insulin-Resistant Subjects. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-446996
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reyna, Sara M.& Tantiwong, Puntip& Cersosimo, Eugenio& DeFronzo, Ralph A.& Sriwijitkamol, Apiradee& Musi, Nicolas. Short-Term Exercise Training Improves Insulin Sensitivity but Does Not Inhibit Inflammatory Pathways in Immune Cells from Insulin-Resistant Subjects. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-446996
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-446996
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر