Studies on Angiotensin-Converting Enzyme InsertionDeletion Polymorphism and Genotype Distributions in Turkish Preeclampsia Patients
المؤلفون المشاركون
Kasap, Mülkiye
Pazarbaşı, Ayfer
Bereketoğlu, Ceyhun
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-25
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Placental, immune and genetic factors are thought to play an important role in preeclampia (PE)’s pathophysiology.
Angiotensin-Converting Enzyme (ACE) plays a vital role in the renin-angiotensin-system (RAS) which regulates blood pressure by converting angiotensin I into a powerfull vasoconstrictor angiotensin II.
A deletion polymorphism (D allele) has been reported to be associated with elevated ACE activity.
The aim of the this study was to investigate whether there is an association between angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and PE.
In this study, 120 preeclamptic and 116 normotensive Turkish pregnant women were genotyped for ACE I/D polymorphism and the distribution of genotype and allele frequencies of this polymorphism in preeclampsia and controls were evaluated.
Codominant, dominant and recessive models were appplied in ACE gene I/D polymorphism.
In the codominant model, DD genotype was found significantly more frequent in preeclampsia than controls (P=0.016).
Moreover, in dominant model (DD frequency versus DI+II frequency) there was a significant relation between DD genotype and preeclampsia (P=0.006).
D allele frequency was 64.6% in preeclampsia while it was 56.1% in controls (P=0.062).
In conclusion, there was significant difference in genotype distribution between preeclampsia and controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bereketoğlu, Ceyhun& Kasap, Mülkiye& Pazarbaşı, Ayfer. 2012. Studies on Angiotensin-Converting Enzyme InsertionDeletion Polymorphism and Genotype Distributions in Turkish Preeclampsia Patients. Journal of Pregnancy،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-447049
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bereketoğlu, Ceyhun…[et al.]. Studies on Angiotensin-Converting Enzyme InsertionDeletion Polymorphism and Genotype Distributions in Turkish Preeclampsia Patients. Journal of Pregnancy No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-447049
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bereketoğlu, Ceyhun& Kasap, Mülkiye& Pazarbaşı, Ayfer. Studies on Angiotensin-Converting Enzyme InsertionDeletion Polymorphism and Genotype Distributions in Turkish Preeclampsia Patients. Journal of Pregnancy. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-447049
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447049
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر