Anesthetic Isoflurane Posttreatment Attenuates Experimental Lung Injury by Inhibiting Inflammation and Apoptosis
المؤلفون المشاركون
Xie, Ke-lang
Wang, Li-feng
Liu, Xin
Chen, Hui-juan
Gao, Chun-fang
Li, Jun-tang
Wang, Hui
Li, Nan-lin
Li, Wei
Hou, Li-chao
Mu, Jing-lan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-17
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
We investigated the effect of 1.4% isoflurane (ISO) on the development of inflammation and apoptosis caused by zymosan (ZY) in mice.
We found that ZY-challenged mice exhibited significant body weight loss, markedly high mortality, and significant lung injury characterized by the deterioration of histopathology, histologic scores, and wet-to-dry ratio after ISO treatment.
ISO dramatically attenuated ZY-induced lung neutrophil recruitment and inflammation, as evidenced by the reduced levels of total cells, neutrophils, and proinflammatory cytokines (i.e., tumor necrosis factor-α, interleukin- (IL-) 1β, IL-6, and macrophage inflammatory protein-2) in bronchoalveolar lavage fluid and of their mRNA expression in lung tissues.
ISO also inhibited ZY-induced expression and activation of nuclear factor-kappaB p65 and inducible nitric oxide synthase in pulmonary tissue.
ZY administration also resulted in the upregulation of heme oxygenase-1 expression and activity in the lung, which was further enhanced by ISO treatment.
Moreover, ISO markedly prevented ZY-induced pulmonary cell apoptosis in mice, as reflected by the decrease in expression of procaspase-8, procaspase-3, cleaved caspase-8, and cleaved caspase-3, as well as in caspase-3 activity and Bcl-2-associated X/B-cell lymphoma 2 ratio.
These results indicate that ISO is a potential therapeutic drug for treating ZY-induced lung injury, and further investigations are warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jun-tang& Wang, Hui& Li, Wei& Wang, Li-feng& Hou, Li-chao& Mu, Jing-lan…[et al.]. 2013. Anesthetic Isoflurane Posttreatment Attenuates Experimental Lung Injury by Inhibiting Inflammation and Apoptosis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-447106
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jun-tang…[et al.]. Anesthetic Isoflurane Posttreatment Attenuates Experimental Lung Injury by Inhibiting Inflammation and Apoptosis. Mediators of Inflammation No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-447106
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jun-tang& Wang, Hui& Li, Wei& Wang, Li-feng& Hou, Li-chao& Mu, Jing-lan…[et al.]. Anesthetic Isoflurane Posttreatment Attenuates Experimental Lung Injury by Inhibiting Inflammation and Apoptosis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-447106
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447106
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر