Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro
المؤلفون المشاركون
Jiang, Xijuan
Fan, Yingchang
Yang, Lin
Ma, Yiwen
Ma, Dongming
Su, Jinling
Wang, Qiang
Zhang, Ruifeng
Guo, Maojuan
Lu, Bin
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Hypercholesterolemia and disruptions of the blood brain barrier (BBB) have been implicated as underlying mechanisms in the pathogenesis of Alzheimer's disease (AD).
Simvastatin therapy may be of benefit in treating AD; however, its mechanism has not been yet fully understood.
Objective.
To explore whether simvastatin could block disruption of BBB induced by cholesterol both in vivo and in vitro.
Methods.
New Zealand rabbits were fed cholesterol-enriched diet with or without simvastatin.
Total cholesterol of serum and brain was measured.
BBB dysfunction was evaluated.
To further test the results in vivo, rat brain microvascular endothelial cells (RBMECs) were stimulated with cholesterol in the presence/absence of simvastatin in vitro.
BBB disruption was evaluated.
Results.
Simvastatin blocked cholesterol-rich diet induced leakage of Evan's blue dye.
Cholesterol content in the serum was affected by simvastatin, but not brain cholesterol.
Simvastatin blocked high-cholesterol medium-induced decrease in TEER and increase in transendothelial FITC-labeled BSA Passage in RBMECs.
Conclusions.
The present study firstly shows that simvastatin improves disturbed BBB function both in vivo and in vitro.
Our data provide that simvastatin may be useful for attenuating disturbed BBB mediated by hypercholesterolemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Xijuan& Guo, Maojuan& Su, Jinling& Lu, Bin& Ma, Dongming& Zhang, Ruifeng…[et al.]. 2012. Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-447146
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Xijuan…[et al.]. Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-447146
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Xijuan& Guo, Maojuan& Su, Jinling& Lu, Bin& Ma, Dongming& Zhang, Ruifeng…[et al.]. Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-447146
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447146
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر