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A Novel Model of Atherosclerosis in Rabbits Using Injury to Arterial Walls Induced by Ferric Chloride as Evaluated by Optical Coherence Tomography as well as Intravascular Ultrasound and Histology
المؤلفون المشاركون
Tian, Jinwei
Hu, Sining
Yu, Bo
Dong, Nana
Ban, Xiang
Yu, Huai
Wu, Jian
Sun, Yanli
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
This study aim was to develop a new model of atherosclerosis by FeCl3-induced injury to right common carotid arteries (CCAs) of rabbits.
Right CCAs were induced in male New Zealand White rabbits (n=15) by combination of a cholesterol-rich diet and FeCl3-induced injury to arterial walls.
The right and left CCAs were evaluated by histology and in vivo intravascular ultrasound (IVUS) and optical coherence tomography (OCT) examinations of 24 hours (n=3), 8 weeks (n=6), and 12 weeks (n=6) after injury.
Each right CCA of the rabbits showed extensive white-yellow plaques.
At eight and 12 weeks after injury, IVUS, OCT, and histological findings demonstrated that the right CCAs had evident eccentric plaques.
Six plaques (50%) with evident positive remodeling were observed.
Marked progression was clearly observed in the same plaque at 12 weeks after injury when it underwent repeat OCT and IVUS.
We demonstrated, for the first time, a novel model of atherosclerosis induced by FeCl3.
The model is simple, fast, inexpensive, and reproducible and has a high success rate.
The eccentric plaques and remodeling of plaques were common in this model.
We successfully carried out IVUS and OCT examinations twice in the same lesion within a relatively long period of time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Jinwei& Hu, Sining& Sun, Yanli& Ban, Xiang& Yu, Huai& Dong, Nana…[et al.]. 2012. A Novel Model of Atherosclerosis in Rabbits Using Injury to Arterial Walls Induced by Ferric Chloride as Evaluated by Optical Coherence Tomography as well as Intravascular Ultrasound and Histology. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-447362
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Jinwei…[et al.]. A Novel Model of Atherosclerosis in Rabbits Using Injury to Arterial Walls Induced by Ferric Chloride as Evaluated by Optical Coherence Tomography as well as Intravascular Ultrasound and Histology. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-447362
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Jinwei& Hu, Sining& Sun, Yanli& Ban, Xiang& Yu, Huai& Dong, Nana…[et al.]. A Novel Model of Atherosclerosis in Rabbits Using Injury to Arterial Walls Induced by Ferric Chloride as Evaluated by Optical Coherence Tomography as well as Intravascular Ultrasound and Histology. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-447362
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447362
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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