Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus : Case Report and Review of the Literature

الملخص EN

Pancreatic neuroendocrine tumors (NETs) are extremely rare, and although insulinomas are the commonest, less than 10% of insulinomas are malignant.

Most patients with insulinomas present with neuroglycopenic symptoms and weight gain attributable to insulin excess.

Here, we report a case where a 67-year-old lady with a background history of type 2 diabetes mellitus and breakthrough hyperinsulinism who presented with coma.

The biochemical profile revealed features typical of insulinoma, and CT and endosonography confirmed a pancreatic tumor with large volume right-sided liver metastases (biopsy confirming a neuroendocrine tumor).

The patient underwent successful one-step RO surgical resection, distal pancreatectomy, splenectomy, and right hepatectomy, and 9 months postoperatively, she remains free of recurrent disease.

She remains a diabetic.