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Baicalein Triggers Mitochondria-Mediated Apoptosis and Enhances the Antileukemic Effect of Vincristine in Childhood Acute Lymphoblastic Leukemia CCRF-CEM Cells
المؤلفون المشاركون
Chen, Hsing-Yu
Wu, Chieh-Shan
Shieh, Jeng-Jer
Chung, Ting-Wen
Chen, Yu-Kuo
Lin, Chi-Chen
Chen, Yun-Ju
Wu, Jyh-Horng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-28
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Acute lymphoblastic leukemia (ALL) accounts for approximately 75% of childhood leukemia, and chemotherapy remains the mainstay therapy.
Baicalein is an active flavonoid used in traditional Chinese medicine and has recently been found to have anticancer, anti-inflammatory, and antiallergic properties.
This study aims to investigate the molecular apoptotic mechanisms of baicalein in CCRF-CEM leukemic cells and to evaluate the combined therapeutic efficacy of baicalein with several commonly used chemotherapeutic drugs in CCRF-CEM cells.
Our results demonstrate that baicalein induces mitochondria-dependent cleavage of caspases-9 and -3 and PARP with concomitant decreases in IAP family proteins, survivin, and XIAP.
Furthermore, our results present for the first time that baicalein triggers a convergence of the intrinsic and extrinsic apoptotic pathways via the death receptor-caspase 8-tBid signaling cascade in CCRF-CEM cells.
In addition, we also present for the first time that the combination of baicalein and vincristine results in a synergistic therapeutic efficacy.
Overall, this combination strategy is recommended for future clinical trials in the treatment of pediatric leukemia owing to baicalein’s beneficial effects in alleviating the vomiting, nausea, and skin rashes caused by chemotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yun-Ju& Wu, Chieh-Shan& Shieh, Jeng-Jer& Wu, Jyh-Horng& Chen, Hsing-Yu& Chung, Ting-Wen…[et al.]. 2013. Baicalein Triggers Mitochondria-Mediated Apoptosis and Enhances the Antileukemic Effect of Vincristine in Childhood Acute Lymphoblastic Leukemia CCRF-CEM Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-447528
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yun-Ju…[et al.]. Baicalein Triggers Mitochondria-Mediated Apoptosis and Enhances the Antileukemic Effect of Vincristine in Childhood Acute Lymphoblastic Leukemia CCRF-CEM Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-447528
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yun-Ju& Wu, Chieh-Shan& Shieh, Jeng-Jer& Wu, Jyh-Horng& Chen, Hsing-Yu& Chung, Ting-Wen…[et al.]. Baicalein Triggers Mitochondria-Mediated Apoptosis and Enhances the Antileukemic Effect of Vincristine in Childhood Acute Lymphoblastic Leukemia CCRF-CEM Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-447528
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447528
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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