Silencing Sexually Transmitted Infections : Topical siRNA-Based Interventions for the Prevention of HIV and HSV
المؤلف
المصدر
Infectious Diseases in Obstetrics and Gynecology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The global impact of sexually transmitted infections (STIs) is significant.
The sexual transmission of viruses such as herpes simplex virus type-2 (HSV-2) and the human immunodeficiency virus type-1 (HIV-1), has been especially difficult to control.
To date, no effective vaccines have been developed to prevent the transmission of these STIs.
Although antiretroviral drugs have been remarkably successful in treating the symptoms associated with these viral infections, the feasibility of their widespread use for prevention purposes may be more limited.
Microbicides might provide an attractive alternative option to reduce their spread.
In particular, topically applied small inhibitory RNAs (siRNAs) have been shown to not only block transmission of viral STIs to mucosal tissues both in vitro and in vivo, but also confer durable knockdown of target gene expression, thereby circumventing the need to apply a microbicide around the time of sexual encounter, when compliance is mostly difficult.
Despite numerous clinical trials currently testing the efficacy of siRNA-based therapeutics, they have yet to be approved for use in the treatment of viral STIs.
While several obstacles to their successful implementation in the clinic still exist, promising preclinical studies suggest that siRNAs are a viable modality for the future prevention and treatment of HSV and HIV.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wheeler, Lee Adam. 2014. Silencing Sexually Transmitted Infections : Topical siRNA-Based Interventions for the Prevention of HIV and HSV. Infectious Diseases in Obstetrics and Gynecology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-447573
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wheeler, Lee Adam. Silencing Sexually Transmitted Infections : Topical siRNA-Based Interventions for the Prevention of HIV and HSV. Infectious Diseases in Obstetrics and Gynecology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-447573
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wheeler, Lee Adam. Silencing Sexually Transmitted Infections : Topical siRNA-Based Interventions for the Prevention of HIV and HSV. Infectious Diseases in Obstetrics and Gynecology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-447573
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447573
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر