Interactions between E-Cadherin and MicroRNA Deregulation in Head and Neck Cancers : The Potential Interplay

المؤلفون المشاركون

Wong, Thian-Sze
Gao, Wei
Chan, Jimmy Yu-Wai

المصدر

BioMed Research International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-08-04

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

E-cadherin expression in the head and neck epithelium is essential for the morphogenesis and homeostasis of epithelial tissues.

The cadherin-mediated cell-cell contacts are required for the anchorage-dependent growth of epithelial cells.

Further, survival and proliferation require physical tethering created by proper cell-cell adhesion.

Otherwise, the squamous epithelial cells will undergo programmed cell death.

Head and neck cancers can escape from anoikis and enter into the epithelial-mesenchymal transition stages via the modulation of E-cadherin expression with epigenetic mechanisms.

At epigenetic level, gene expression control is not dependent on the DNA sequence.

In the context of E-cadherin regulation in head and neck cancers, 2 major mechanisms including de novo promoter hypermethylation and microRNA dysregulation are most extensively studied.

Both of them control E-cadherin expression at transcription level and subsequently hinder the overall E-cadherin protein level in the head and neck cancer cells.

Increasing evidence suggested that microRNA mediated E-cadherin expression in the head and neck cancers by directly/indirectly targeting the transcription suppressors of E-cadherin, ZEB1 and ZEB2.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wong, Thian-Sze& Gao, Wei& Chan, Jimmy Yu-Wai. 2014. Interactions between E-Cadherin and MicroRNA Deregulation in Head and Neck Cancers : The Potential Interplay. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-447671

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wong, Thian-Sze…[et al.]. Interactions between E-Cadherin and MicroRNA Deregulation in Head and Neck Cancers : The Potential Interplay. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-447671

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wong, Thian-Sze& Gao, Wei& Chan, Jimmy Yu-Wai. Interactions between E-Cadherin and MicroRNA Deregulation in Head and Neck Cancers : The Potential Interplay. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-447671

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-447671