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Entamoeba histolytica and E. dispar Calreticulin : Inhibition of Classical Complement Pathway and Differences in the Level of Expression in Amoebic Liver Abscess
المؤلفون المشاركون
García de León, Ma del Carmen
Morán, Patricia
Escobar-Herrera, Jaime
Cerritos, René
Valadez, Alicia
Ximénez, Cecilia
Nieves, Miriam E.
Shibayama, Mineko
Partida, Oswaldo
Silva-Olivares, Angélica
Galindo-Gómez, Silvia
Rojas, Liliana
González, Enrique
Hernández, Eric G.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The role of calreticulin (CRT) in host-parasite interactions has recently become an important area of research.
Information about the functions of calreticulin and its relevance to the physiology of Entamoeba parasites is limited.
The present work demonstrates that CRT of both pathogenic E.
histolytica and nonpathogenic E.
dispar species specifically interacted with human C1q inhibiting the activation of the classical complement pathway.
Using recombinant EhCRT protein, we demonstrate that CRT interaction site and human C1q is located at the N-terminal region of EhCRT.
The immunofluorescence and confocal microscopy experiments show that CRT and human C1q colocalize in the cytoplasmic vesicles and near to the surface membrane of previously permeabilized trophozoites or are incubated with normal human serum which is known to destroy trophozoites.
In the presence of peripheral mononuclear blood cells, the distribution of EhCRT and C1q is clearly over the surface membrane of trophozoites.
Nevertheless, the level of expression of CRT in situ in lesions of amoebic liver abscess (ALA) in the hamster model is different in both Entamoeba species; this molecule is expressed in higher levels in E.
histolytica than in E.
dispar.
This result suggests that EhCRT may modulate some functions during the early moments of the host-parasite relationship.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ximénez, Cecilia& González, Enrique& Nieves, Miriam E.& Silva-Olivares, Angélica& Shibayama, Mineko& Galindo-Gómez, Silvia…[et al.]. 2014. Entamoeba histolytica and E. dispar Calreticulin : Inhibition of Classical Complement Pathway and Differences in the Level of Expression in Amoebic Liver Abscess. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-447800
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ximénez, Cecilia…[et al.]. Entamoeba histolytica and E. dispar Calreticulin : Inhibition of Classical Complement Pathway and Differences in the Level of Expression in Amoebic Liver Abscess. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-447800
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ximénez, Cecilia& González, Enrique& Nieves, Miriam E.& Silva-Olivares, Angélica& Shibayama, Mineko& Galindo-Gómez, Silvia…[et al.]. Entamoeba histolytica and E. dispar Calreticulin : Inhibition of Classical Complement Pathway and Differences in the Level of Expression in Amoebic Liver Abscess. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-447800
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447800
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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